Retinoblastoma protein: Difference between revisions
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Retinoblastoma protein (pRb) is a tumour suppressor protein which acts as a cell cycle checkpoint at G1 phase. pRb prevents progression of damaged cells from G1 phase to [[ | Retinoblastoma protein (pRb) is a tumour suppressor protein which acts as a cell cycle checkpoint at G1 phase. pRb prevents progression of damaged cells from G1 phase to [[S phase|S phase]] of the cell cycle to disable abnormal cell replication which might develop a benign or malignant tumour<ref>Goodrich DW, Wang NP, Qian YW, Lee EY, Lee WH (November 1991). "The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle". Cell. 67 (2): 293–302</ref><ref>Emmi Rotgers1, Mirja Nurmio1, Sheyla Cisneros-Montalvo and Jorma Toppari1 University of Turku, Turku, Finland (April 2, 2016)Endocrine Society's 98th Annual Meeting and Expo, April 1–4, 2016 - Boston LBSat-11: Retinoblastoma Protein Negatively Regulates E2F3 Transcription Factor to Maintain Adult Sertoli Cell Quiescence</ref>. By binding to and inactivating the [[Transcription factors|transcription factors]] that allow cells entering S phase, pRb can suppress cell replication and keep the target cell in G1 phase<ref>de Jager SM, Maughan S, Dewitte W, Scofield S, Murray JA (June 2005). "The developmental context of cell-cycle control in plants". Semin. Cell Dev. Biol. 16 (3): 385–96</ref>. | ||
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Latest revision as of 19:48, 5 December 2017
Retinoblastoma protein (pRb) is a tumour suppressor protein which acts as a cell cycle checkpoint at G1 phase. pRb prevents progression of damaged cells from G1 phase to S phase of the cell cycle to disable abnormal cell replication which might develop a benign or malignant tumour[1][2]. By binding to and inactivating the transcription factors that allow cells entering S phase, pRb can suppress cell replication and keep the target cell in G1 phase[3].
References
- ↑ Goodrich DW, Wang NP, Qian YW, Lee EY, Lee WH (November 1991). "The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle". Cell. 67 (2): 293–302
- ↑ Emmi Rotgers1, Mirja Nurmio1, Sheyla Cisneros-Montalvo and Jorma Toppari1 University of Turku, Turku, Finland (April 2, 2016)Endocrine Society's 98th Annual Meeting and Expo, April 1–4, 2016 - Boston LBSat-11: Retinoblastoma Protein Negatively Regulates E2F3 Transcription Factor to Maintain Adult Sertoli Cell Quiescence
- ↑ de Jager SM, Maughan S, Dewitte W, Scofield S, Murray JA (June 2005). "The developmental context of cell-cycle control in plants". Semin. Cell Dev. Biol. 16 (3): 385–96