Histone Methylation: Difference between revisions
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Histone methylation is an [[Epigenetics|epigenetic modification]] resulting in a change in [[Gene expression|gene expression]]. It is a [[Post-translational modification|post-translational modification]] where between one and three [[Methyl group|methyl groups]] are added to [[Lysine|lysine]] or [[Arginine|arginine]] residues in a histone tail by the enzyme histone methyltransferase<ref>Armstrong L. Epigenetics. United States of America: Garland Science; 2014.</ref>. Note that the number of methyl groups added is significant and may have a different effect on gene expression. Whereas other post-translational modifications such as [[Histone Acetylation|histone acetylation]] have a set effect on gene expression, histone methylation can either repress or activate gene expression. This is because methylation does not immediately result in a change in gene expression, but recruits proteins which either stimulate or inhibit [[DNA transcription|transcription]], by creating binding sites<ref>Griffiths AJF, Wessler SR, Carroll SB, Doebley J. Introduction to genetic analysis, 11th ed. United States of America: W.H. Freeman and Company; 2015.</ref>. | |||
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Latest revision as of 22:13, 5 December 2017
Histone methylation is an epigenetic modification resulting in a change in gene expression. It is a post-translational modification where between one and three methyl groups are added to lysine or arginine residues in a histone tail by the enzyme histone methyltransferase[1]. Note that the number of methyl groups added is significant and may have a different effect on gene expression. Whereas other post-translational modifications such as histone acetylation have a set effect on gene expression, histone methylation can either repress or activate gene expression. This is because methylation does not immediately result in a change in gene expression, but recruits proteins which either stimulate or inhibit transcription, by creating binding sites[2].