Ligand-gated sodium channels: Difference between revisions
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Revision as of 23:53, 5 December 2017
Ligand gated Na+ channels are found in the post synaptic membrane of the neuromuscular junction (1). After a neurotransmitter (acetylcholine) binds to its receptor the channel opens (undergoes a conformational change) allowing Na+ to enter the motor endplate and K+ to flow out (1) (2). This causes the motor endplate to depolarise. If the end plate potential reaches a high enough potential it will go on to trigger an action potential in the cell (1).
References
1. Alberts, et al. Essential Cell Biology. 4th edition. Abingdon. Garland science. Page 410-412
2. Mheducationcom. Animation: Receptors Linked to a Channel Protein. [Accessed 5 December 2017]. Available from: http://highered.mheducation.com/sites/0072495855/student_view0/chapter2/animation__receptors_linked_to_a_channel_protein.html