GTP: Difference between revisions
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Guanosine triphosphate (GTP) is a ribose nucleotide. It is similar to [[ATP|ATP]] which is widely utilised in many cellular processes as a source of energy. Dephosphorylation of GTP also yields energy, but the use of GTP in this manner is more specific to certain metabolic pathways. | [[Image:GTP chemical structure.png|border|right|4282x2071px|Displayed formula of guanosine triphosphate showing the three regions of the molecule: the guanine base, ribose sugar and the triphosphate arm.]]Guanosine triphosphate (GTP) is a ribose nucleotide. It is similar to [[ATP|ATP]] which is widely utilised in many cellular processes as a source of energy. Dephosphorylation of GTP also yields energy, but the use of GTP in this manner is more specific to certain metabolic pathways. | ||
GTP is used in protein synthesis. During initiation of translation, the GTP is associated with an initiation factor 2 (IF<sub>2</sub>) and is hydrolysed upon the assembly of the initiation ribosomal complex. During elongation, GTP facilitates the binding of a new aminoacyl tRNA to the A site at a ribosome. | GTP is used in protein synthesis. During initiation of translation, the GTP is associated with an initiation factor 2 (IF<sub>2</sub>) and is hydrolysed upon the assembly of the initiation ribosomal complex. During elongation, GTP facilitates the binding of a new aminoacyl tRNA to the A site at a ribosome. | ||
GTP is also an important factor in signal transduction pathways. Here, GTP can be associated with [[G-proteins|G-protein ]] | GTP is also an important factor in signal transduction pathways. Here, GTP can be associated with [[G-proteins|G-protein complexes]] and is used to regulate the activity of the protein by phosphorylation. | ||
Revision as of 12:31, 3 December 2010
Guanosine triphosphate (GTP) is a ribose nucleotide. It is similar to ATP which is widely utilised in many cellular processes as a source of energy. Dephosphorylation of GTP also yields energy, but the use of GTP in this manner is more specific to certain metabolic pathways.
GTP is used in protein synthesis. During initiation of translation, the GTP is associated with an initiation factor 2 (IF2) and is hydrolysed upon the assembly of the initiation ribosomal complex. During elongation, GTP facilitates the binding of a new aminoacyl tRNA to the A site at a ribosome.
GTP is also an important factor in signal transduction pathways. Here, GTP can be associated with G-protein complexes and is used to regulate the activity of the protein by phosphorylation.