Hypoxia inducible factor: Difference between revisions
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Hypoxia Inducible Factor (HIF) is a [[Heterodimeric transcription factor|heterodimeric transcription factor]] which responds to the relative lowering of the [[Oxygen|oxygen]] concentration in a [[Cells|cell]] ([[Hypoxia|hypoxia]]) | Hypoxia Inducible Factor (HIF) is a [[Heterodimeric transcription factor|heterodimeric transcription factor]] which responds to the relative lowering of the [[Oxygen|oxygen]] concentration in a [[Cells|cell]] ([[Hypoxia|hypoxia]])<ref>Jennifer E. Ziello, Y. (2017). Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway and its Potential for Therapeutic Intervention in Malignancy and Ischemia. [online] PubMed Central (PMC). Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140184/ [Accessed 20 Oct. 2017]</ref>. | ||
Hypoxia can be defined as lowering of oxygen levels compared to sea levels (~20.9%) | Hypoxia can be defined as a lowering of oxygen levels compared to sea levels (~20.9%) | ||
HIFs come in two flavours: '''HIF-α''' (HIF-1α, HIF-2α, HIF-3α) and '''HIF-1β'''. | HIFs come in two flavours: '''HIF-α''' (HIF-1α, HIF-2α, HIF-3α) and '''HIF-1β'''. | ||
Under normal oxygen levels HIF-1α is constantly made and degraded via [[Ubiquitination|ubiquitination]]. | Under normal oxygen levels, HIF-1α is constantly made and degraded via [[Ubiquitination|ubiquitination]]. | ||
However, when oxygen levels are low (hypoxia) HIF-1α can escape this translational block so that it’s no longer degraded and is still being made in hypoxia. | However, when oxygen levels are low (hypoxia) HIF-1α can escape this translational block so that it’s no longer degraded and is still being made in hypoxia. | ||
As a result, HIF-1α is stabilsed and able to dimerise with HIF-1β to activate target [[Gene expression|gene expression]] via recruitment of [[ | As a result, HIF-1α is stabilsed and able to dimerise with HIF-1β to activate target [[Gene expression|gene expression]] via recruitment of [[ATP chromatin remodelling|co-factors]]<ref>Kenneth , N.S, Rocha, S. Regulation of gene expression by hypoxia. Biochemical journal. 2008;141(1): 19-29.</ref>. | ||
=== Reference === | === Reference === | ||
<references /> | <references /><br> | ||
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Latest revision as of 20:51, 22 October 2018
Hypoxia Inducible Factor (HIF) is a heterodimeric transcription factor which responds to the relative lowering of the oxygen concentration in a cell (hypoxia)[1].
Hypoxia can be defined as a lowering of oxygen levels compared to sea levels (~20.9%)
HIFs come in two flavours: HIF-α (HIF-1α, HIF-2α, HIF-3α) and HIF-1β.
Under normal oxygen levels, HIF-1α is constantly made and degraded via ubiquitination.
However, when oxygen levels are low (hypoxia) HIF-1α can escape this translational block so that it’s no longer degraded and is still being made in hypoxia.
As a result, HIF-1α is stabilsed and able to dimerise with HIF-1β to activate target gene expression via recruitment of co-factors[2].
Reference
- ↑ Jennifer E. Ziello, Y. (2017). Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway and its Potential for Therapeutic Intervention in Malignancy and Ischemia. [online] PubMed Central (PMC). Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140184/ [Accessed 20 Oct. 2017]
- ↑ Kenneth , N.S, Rocha, S. Regulation of gene expression by hypoxia. Biochemical journal. 2008;141(1): 19-29.