T-cell receptor: Difference between revisions
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One of their key characteristics is their diversity, allowing for recognition of many different [[Antigens|antigens]]. | One of their key characteristics is their diversity, allowing for recognition of many different [[Antigens|antigens]]. | ||
Similar to [[B-cells|B cells]], they are produced in the [[Bone marrow|bone marrow]], however, [[Differentiation|differentiate]] in the [[Thymus|thymus]] by breaking and rearranging their [[Gene|genes]] (whereas [[B-cells|B cells]] differentiate in the [[Bone marrow|bone marrow]]). Following exit from the [[Thymus|thymus]], the T cells are known as naive T cells as they have not yet encountered an [[Antigens|antigen]], | Similar to [[B-cells|B cells]], they are produced in the [[Bone marrow|bone marrow]], however, [[Differentiation|differentiate]] in the [[Thymus|thymus]] by breaking and rearranging their [[Gene|genes]] (whereas [[B-cells|B cells]] differentiate in the [[Bone marrow|bone marrow]]). Following exit from the [[Thymus|thymus]], the T cells are known as naive T cells as they have not yet encountered an [[Antigens|antigen]], presented to them by an MHC molecules on the surface of APCs. They recirculate via the blood/lymphatics through secondary lymphoid tissue. | ||
Their variable regions are encoded by V, D and J segments, which can arrange in any format, which is what allows them to be so diverse. | Their variable regions are encoded by V, D and J segments, which can arrange in any format, which is what allows them to be so diverse. | ||
Latest revision as of 10:39, 23 October 2018
T-cell receptors (also known as TCRs) are an incredibly important part of immunology.
One of their key characteristics is their diversity, allowing for recognition of many different antigens.
Similar to B cells, they are produced in the bone marrow, however, differentiate in the thymus by breaking and rearranging their genes (whereas B cells differentiate in the bone marrow). Following exit from the thymus, the T cells are known as naive T cells as they have not yet encountered an antigen, presented to them by an MHC molecules on the surface of APCs. They recirculate via the blood/lymphatics through secondary lymphoid tissue.
Their variable regions are encoded by V, D and J segments, which can arrange in any format, which is what allows them to be so diverse.