Rattus norvegicus: Difference between revisions
No edit summary |
No edit summary |
||
| (3 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
'' | ''Rattus norvegicus ''is a brown lab rat also known as the Norway rat. | ||
They are a commonly used model organism | They are a commonly used [[Model organism|model organism]] for studying different processes in humans, as they can mimic human diseases pretty well<ref>DNA Learning Centre. Rat (Rattus norvegicus). [Cited 22/10/2018]. Available from: https://www.dnalc.org/view/1717-Rat-Rattus-norvegicus-.html</ref>. | ||
It is also the first mammalian species that was utilised for | It is also the first mammalian species that was utilised for scientific research, hence is the most extensively used model animal in research. | ||
It is a | It is a convenient model organism due to its smaller size, rapid life cycle, similarity to humans and they are relatively affordable. There are also a large number of mutants available and you can even manipulate the [[Genome|genome]]. | ||
They have been used for a vast array of research including | They have been used for a vast array of research including ageing, addiction, cancer, genomics, cardiovascular diseases and many more<ref>Genome Research. Functional Genomics and Rat Models. [Cited 22/10/18]; Available at: https://genome.cshlp.org/content/9/11/1013.full.html</ref>. | ||
The first known research done in ''Rattus norvegicus'' was in America in 1908 by Elmer McCollun Day<ref>Day, Harry G. (1974). "Elmer Verner McCollum". Biographical Memoirs. National Academy of Sciences (U.S.). 45: 291. PMID 11615648</ref>, they originally used them for trials for basic nutrition. A further experiment took place the determine protein digestion by Thomas Burr Osbourne. | |||
=== References === | === References === | ||
<references /> | <references /> | ||
Latest revision as of 16:07, 24 October 2018
Rattus norvegicus is a brown lab rat also known as the Norway rat.
They are a commonly used model organism for studying different processes in humans, as they can mimic human diseases pretty well[1].
It is also the first mammalian species that was utilised for scientific research, hence is the most extensively used model animal in research.
It is a convenient model organism due to its smaller size, rapid life cycle, similarity to humans and they are relatively affordable. There are also a large number of mutants available and you can even manipulate the genome.
They have been used for a vast array of research including ageing, addiction, cancer, genomics, cardiovascular diseases and many more[2].
The first known research done in Rattus norvegicus was in America in 1908 by Elmer McCollun Day[3], they originally used them for trials for basic nutrition. A further experiment took place the determine protein digestion by Thomas Burr Osbourne.
References
- ↑ DNA Learning Centre. Rat (Rattus norvegicus). [Cited 22/10/2018]. Available from: https://www.dnalc.org/view/1717-Rat-Rattus-norvegicus-.html
- ↑ Genome Research. Functional Genomics and Rat Models. [Cited 22/10/18]; Available at: https://genome.cshlp.org/content/9/11/1013.full.html
- ↑ Day, Harry G. (1974). "Elmer Verner McCollum". Biographical Memoirs. National Academy of Sciences (U.S.). 45: 291. PMID 11615648