Sequence degeneracy: Difference between revisions
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Added more detail to the definition and an example of how to work out degeneracy from a protein sequence |
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Sequence Degeneracy | Sequence Degeneracy occurs as a result of back translating a [[Protein sequence|protein sequence]] into a [[DNA sequence|DNA sequence]]. <br><br>Degeneracy occurs when back translating a [[Protein sequence|protein sequence]] due to the many different combinations of bases that can create the same [[Amino acid|amino acid]] sequnce. <br>However [[DNA sequences|DNA sequences]] with ambiguous bases can be accounted for using the [[IUB|IUB]] and [[IUB Complement|complement code]] to work out the correct [[Reverse translation|reverse translation]]. <br>For example, the protein sequence 'SCIENCE' contains the [[Amino acids|amino acids]]: Serine, Cysteine, Isoleucine, Glutamic, Asparagine, Cysteine and Glutamic respectively, <br>however as each of these amino acids can be encoded by more than one t[[Triplet code|riplet]], ambiguity arises. <br><br>In this instance: 'SCIENCE'<br>Serine = 6 possible codons <br>Cysteine = 2 possible codons <br>Isoleucine = 3 possible codons<br>Glutamic = 2 possible codons <br>Asparagine = 2 possible codons <br>Cysteine = 2 possible codons<br>Glutamic = 2 possible codons <br><br>The degeneracy of the sequence can be determined through the multpiplication of the number of possible [[Codons|codons]] at each amino acid on the sequence. <br>Degeneracy in this case is: 6 x 2 x 3 x 2 x 2 x 2 x 2 = 576 <br><br> | ||
Bioinformatica.upf.edu. (2018). SNPs in Human Selenoproteins Genes. [online] Available at:[[Javascript:void(0);/*1540564120009*/|http://bioinformatica.upf.edu/2005/projectes05/3.2.4/material.html ]]<br> | |||
Revision as of 14:35, 26 October 2018
Sequence Degeneracy occurs as a result of back translating a protein sequence into a DNA sequence.
Degeneracy occurs when back translating a protein sequence due to the many different combinations of bases that can create the same amino acid sequnce.
However DNA sequences with ambiguous bases can be accounted for using the IUB and complement code to work out the correct reverse translation.
For example, the protein sequence 'SCIENCE' contains the amino acids: Serine, Cysteine, Isoleucine, Glutamic, Asparagine, Cysteine and Glutamic respectively,
however as each of these amino acids can be encoded by more than one triplet, ambiguity arises.
In this instance: 'SCIENCE'
Serine = 6 possible codons
Cysteine = 2 possible codons
Isoleucine = 3 possible codons
Glutamic = 2 possible codons
Asparagine = 2 possible codons
Cysteine = 2 possible codons
Glutamic = 2 possible codons
The degeneracy of the sequence can be determined through the multpiplication of the number of possible codons at each amino acid on the sequence.
Degeneracy in this case is: 6 x 2 x 3 x 2 x 2 x 2 x 2 = 576
Bioinformatica.upf.edu. (2018). SNPs in Human Selenoproteins Genes. [online] Available at:http://bioinformatica.upf.edu/2005/projectes05/3.2.4/material.html