Ubiquinone: Difference between revisions
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Ubiquinone is a [[Quinone|quinone]] found in the [[Lipid bilayer|lipid bilayer]] and involved in the respiratory [[Electron transport chain|electron transport chain]] as an [[Electron carrier|electron carrier]] <ref>Alberts et al (2008) Molecular Biology of the Cell, 5th edition, New York: Garland Science. Chapter 14, Page 831</ref>. As an electron carrier ubiquinone donates or picks up [[Electrons|electrons]] in redox reactions. Ubiquinone is a small [[Hydrophobic|hydrophobic]] molecule ubiquinone has the ability to move easily through the [[Lipid bilayer|lipid bilayer]] and is not located in a fixed position. | Ubiquinone is a [[Quinone|quinone]] found in the [[Lipid bilayer|lipid bilayer]] and involved in the respiratory [[Electron transport chain|electron transport chain]] as an [[Electron carrier|electron carrier]] <ref>Alberts et al (2008) Molecular Biology of the Cell, 5th edition, New York: Garland Science. Chapter 14, Page 831</ref>. As an electron carrier ubiquinone donates or picks up [[Electrons|electrons]] in redox reactions. Ubiquinone is a small [[Hydrophobic|hydrophobic]] molecule ubiquinone has the ability to move easily through the [[Lipid bilayer|lipid bilayer]] and is not located in a fixed position. | ||
Ubiquinone, also known as [[ | Ubiquinone, also known as [[Coenzyme Q|coenzyme Q]], plays an important role in the electron transport chain in mitochondria<ref>Sarah L Molyneux,1,* Joanna M Young,2 Christopher M Florkowski,1,2 Michael Lever,1 and Peter M George1. Coenzyme Q10: Is There a Clinical Role and a Case for Measurement? Clin Biochem Rev. 2008 May; 29(2): 71–82.</ref>. Coenzyme Q <span style="font-size: 13.28px;">transfers electrons from complex I and complex II to complex III in the electron transport chain and is synthesised in all eukaryotic cells<ref>Trends Biochem Sci. 2017 Oct; 42(10): 824–843. Molecular Genetics of Ubiquinone Biosynthesis in Animals. Crit Rev Biochem Mol Biol. 2013 Jan-Feb; 48(1): 69–88.</ref> </span><span style="font-size: 13.28px;">. Due to the fact that ubiquinone is essential in the production of </span>[[ATP|ATP]]<span style="font-size: 13.28px;">, a deficiency in the </span>[[Cofactor|cofactor]]<span style="font-size: 13.28px;"> can result in multiple diseases including </span>[[Myopathies|myopathies <ref>Jonathan A. Stefely1,2,3 and David J. Pagliarini1,2,*. Biochemistry of Mitochondrial Coenzyme Q Biosynthesis. Trends Biochem Sci. 2017 Oct; 42(10): 824–843.</ref>]]<span style="font-size: 13.28px;">.</span> | ||
=== References === | === References === | ||
<references /> | <references /> | ||
Revision as of 12:58, 5 December 2018
Ubiquinone is a quinone found in the lipid bilayer and involved in the respiratory electron transport chain as an electron carrier [1]. As an electron carrier ubiquinone donates or picks up electrons in redox reactions. Ubiquinone is a small hydrophobic molecule ubiquinone has the ability to move easily through the lipid bilayer and is not located in a fixed position.
Ubiquinone, also known as coenzyme Q, plays an important role in the electron transport chain in mitochondria[2]. Coenzyme Q transfers electrons from complex I and complex II to complex III in the electron transport chain and is synthesised in all eukaryotic cells[3] . Due to the fact that ubiquinone is essential in the production of ATP, a deficiency in the cofactor can result in multiple diseases including myopathies [4].
References
- ↑ Alberts et al (2008) Molecular Biology of the Cell, 5th edition, New York: Garland Science. Chapter 14, Page 831
- ↑ Sarah L Molyneux,1,* Joanna M Young,2 Christopher M Florkowski,1,2 Michael Lever,1 and Peter M George1. Coenzyme Q10: Is There a Clinical Role and a Case for Measurement? Clin Biochem Rev. 2008 May; 29(2): 71–82.
- ↑ Trends Biochem Sci. 2017 Oct; 42(10): 824–843. Molecular Genetics of Ubiquinone Biosynthesis in Animals. Crit Rev Biochem Mol Biol. 2013 Jan-Feb; 48(1): 69–88.
- ↑ Jonathan A. Stefely1,2,3 and David J. Pagliarini1,2,*. Biochemistry of Mitochondrial Coenzyme Q Biosynthesis. Trends Biochem Sci. 2017 Oct; 42(10): 824–843.