Cyclin: Difference between revisions
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Created page with "Cyclins are a group of proteins used within the cell cycle. They form complexes with Cdk proteins and these complexes [[Phosphorylation|phosphorylate..." |
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Revision as of 15:25, 14 November 2011
Cyclins are a group of proteins used within the cell cycle. They form complexes with Cdk proteins and these complexes phosphorylate other proteins during control stages of the cell cycle.
Cyclins determine substrate specificity and are a very diverse family of proteins (35 - 90 kDa).
There are several different cyclins within Mammals and they all bind to different Cdks:
- Cyclin D1-3 bind to Cdk 4 & Cdk 6 - present during G1
- Cyclin E binds to Cdk 2 - present at the Restriction Point
- Cyclin A binds to Cdk 2 - present during S phase
- Cyclin B binds to Cdk 1 - present during G2