Calmodulin: Difference between revisions
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Calmodulin functions as a multi-purpose intracellular receptor,governing many Ca2+ regulated processes. <ref>Alberts et al. Molecular Biology of the Cell (5th Ed).</ref> | Calmodulin functions as a multi-purpose intracellular receptor,governing many Ca2+ regulated processes. <ref>Alberts et al. Molecular Biology of the Cell (5th Ed).</ref> | ||
Two or more Ca<sup>2+</sup> ions bind to induce a [[Conformational change|conformational change]] and activate calmodulin <ref>Alberts et al. Molecular Biology of the Cell (5th Ed)</ref>. | Two or more Ca<sup>2+</sup> ions bind to induce a [[Conformational change|conformational change]] and activate calmodulin <ref>Alberts et al. Molecular Biology of the Cell (5th Ed)</ref>. This results in amplifying the affinity of Ca<sup>2+</sup> molecule which later affects other signalling components such as Ca<sup>2+</sup>/calmodulin-dependent protein kinases (CaMKs), myosin light chain kinase (MLCK), phosphorylase kinase, neuromodulin and so on. <ref>http://www.cell-signalling.org/csb/004/csb004.pdf</ref> | ||
=== References === | === References === | ||
<references /> | <references /> | ||
Revision as of 16:36, 28 November 2011
Calcium binding protein involved in intracellular calcium signalling. [1]
Structure
Highly conserved sequence of 152 amino acids [2]
There are four EFh domains which are responsible to bind 4 Ca2+ molecules[3]
The arrangement of the Ca2+ binding sites are brought about by the N- and C- terminal lobes.[4]
Calmodulin are dumbbell shaped protein where long and flexible alpha helix connects two globular domains. Each domain is assembled from two EF-hand regions attached to antiparalel beta-sheet. Ca2+ binds to glutamate and aspartate residues placed in the loop of EF-hand.[5]
Function
Calmodulin functions as a multi-purpose intracellular receptor,governing many Ca2+ regulated processes. [6]
Two or more Ca2+ ions bind to induce a conformational change and activate calmodulin [7]. This results in amplifying the affinity of Ca2+ molecule which later affects other signalling components such as Ca2+/calmodulin-dependent protein kinases (CaMKs), myosin light chain kinase (MLCK), phosphorylase kinase, neuromodulin and so on. [8]
References
- ↑ Alberts et al. Molecular Biology of the Cell (5th Ed)
- ↑ http://www.ncbi.nlm.nih.gov/protein/CAA36839.1
- ↑ http://smart.embl-heidelberg.de/smart/job_status.pl?jobid=939661123169621289746763YwAuDuwGQT
- ↑ http://www.cell-signalling.org/csb/004/csb004.pdf
- ↑ John T.Hancock (2005).Cell signalling. New York:Oxford University press
- ↑ Alberts et al. Molecular Biology of the Cell (5th Ed).
- ↑ Alberts et al. Molecular Biology of the Cell (5th Ed)
- ↑ http://www.cell-signalling.org/csb/004/csb004.pdf