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| Rough [[Endoplasmic reticulum|endoplasmic reticulum]] is an organelle found in [[Eukaryotic cells|eukaryotic cells]]. Its main function is to produce [[Proteins|proteins]]. <br>It is made up of cisternae, tubules and [[Vesicles|vesicles]]. The cisternae are made up of flattened membrane disks, which are involved in the modification of [[Proteins|proteins]]. They are held together by the [[Cytoskeleton|cytoskeleton]]. The rough [[Endoplasmic reticulum|endoplasmic reticulum]] also contains a [[Perinuclear space|perinuclear space]], which is the space between the inner and outer [[Phospholipid|phospholipid]] membrane. The membrane is continuous to the [[Nuclear membrane|nuclear membrane]]. However, it isn’t continuous to the [[Golgi apparatus|Golgi apparatus]]. [[Proteins|Proteins]] are transferred from the Rough endoplasmic reticulum to the [[Golgi apparatus|Golgi apparatus]] via membrane-bound vesicles. <br>The reason why it is rough endoplasmic reticulum is because of the [[Ribosomes|ribosomes]] attached to the [[Endoplasmic reticulum|endoplasmic reticulum]]. These [[Ribosomes|ribosomes]] are constantly being attached and detached from the ER because they are not part of the stable [[Organelles|organelle]]. They attach when the [[Ribosomes|ribosome]] begins to synthesis a [[Proteins|protein]] which is going to be secreted ([[Secretory pathway|secretory pathway]]).<br>Rough [[Endoplasmic reticulum|endoplasmic reticulum]] has a number of functions. One of the main functions of the rough [[Endoplasmic reticulum|endoplasmic reticulum]] is to produce and process specific proteins. These are the exported through the [[Secretory pathway|secretory pathway]]. After they are exported via membrane [[Vesicles|vesicles]], they can be sent to the [[Golgi apparatus|Golgi Apparatus]] to be further processed or to [[Organelles|organelles]]. They can even be exported to outside the cell and into another part of the body. [[Ribosomes|Ribosomes]] also create [[proteins|proteins]] which are embedded into the rough endoplasmic reticulum for further processing (integral membrane proteins). Water soluble proteins are created too, which are exported through the membrane into the lumen <ref>http://www.buzzle.com/articles/rough-endoplasmic-reticulum-function.html</ref>. <br>
| | See [[Rough_Endoplasmic_Reticulum|Rough Endoplasmic Reticulum]] |
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| === References ===
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| <references />
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Latest revision as of 22:20, 1 December 2011