Heterotrimeric G-proteins: Difference between revisions
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Revision as of 10:44, 11 November 2010
Heterotrimeric G-proteins are made up of three subunits: alpha, beta and gamma. In its resting state, the three subunits are associated together, and GDP is bound to the alpha subunit. The alpha subunit has GTP-hydrolysis activity.
On activation of the receptor, the alpha unit releases GDP and binds GTP, and dissociates from the other subunits. The beta and gamma subunits form a dimer.