Tubulin: Difference between revisions
Created page with " Tubulin is a globular protein of which there are two forms; alpha and beta. These "homologous 50kd subunits. . . assemble in a helical array of alternating tubulin types" t..." |
No edit summary |
||
| (2 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
Tubulin is a [[Globular protein|globular protein]] of which there are two forms; alpha and beta. These "homologous 50 kDa subunits. . . assemble in a helical array of alternating tubulin types" to form [[Microtubules|microtubules]]. Electron crystallography was used to analyse the 3-D strucutre of tubulin, it was found that "tubulins are members of the [[P-loop NTPase family|P-loop NTPase family]] and contain a [[Nucelotide-binding site|nucelotide-binding site]] adjacent to the P-loop". It was also deteremined that alpha and beta types show high levels of similarity. It is thought that tubulin only exists in [[Eukaryote|eukaryotes]], although a [[Prokaryote|prokaryote]] homolog has been identified, protein FtsZ. "This protein particitpates in [[Bacterial cell division|bacterial cell division]], forming ring structures. These observations suggest that tubulins may have been evolved from ancient cell-division protein." <ref>Berg, Tymoczko and Stryer.(2006). Biochemistry. sixth edition. (page 989-990)</ref><ref>Berg, tymoczko and Stryer. (2006). Biochemistry. sixth edition.</ref> | |||
=== References === | |||
<references /> | |||
Latest revision as of 10:50, 24 October 2012
Tubulin is a globular protein of which there are two forms; alpha and beta. These "homologous 50 kDa subunits. . . assemble in a helical array of alternating tubulin types" to form microtubules. Electron crystallography was used to analyse the 3-D strucutre of tubulin, it was found that "tubulins are members of the P-loop NTPase family and contain a nucelotide-binding site adjacent to the P-loop". It was also deteremined that alpha and beta types show high levels of similarity. It is thought that tubulin only exists in eukaryotes, although a prokaryote homolog has been identified, protein FtsZ. "This protein particitpates in bacterial cell division, forming ring structures. These observations suggest that tubulins may have been evolved from ancient cell-division protein." [1][2]