MicroRNA: Difference between revisions
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MicroRNAs (miRNA) are non-coding [[RNA|RNA]] around 22 [[Nucleotides|nucleotides]] in length. They are responsible for gene expression and preventing translation of mRNA. miRNAs are highly conserved in evolutionary terms | MicroRNAs (miRNA) are non-coding [[RNA|RNA]] around 22 [[Nucleotides|nucleotides]] in length. They are responsible for [[Gene|gene]] [[Gene expression|expression]] and preventing translation of [[MRNA|mRNA]]. miRNAs are highly conserved in evolutionary terms <ref>S.Roush &amp;amp;amp;amp;amp;amp; F.J. Slack (2008), Trends in Cell Biology, 18(10), 505-516</ref>. | ||
Precursors to miRNA are made by [[RNA Polymerase|RNA Polymerase II]]. These precursors are then processed and incorporated into a set of proteins to create an ''RNA-Induced Silencing | Precursors to miRNA are made by [[RNA Polymerase|RNA Polymerase II]]. These precursors are then processed and incorporated into a set of proteins to create an ''RNA-Induced Silencing Complex ''<ref>Alberts et al., Molecular Biology of the Cell, 5th edition, page 494.</ref>. | ||
miRNA are capable of regulating many RNA and in combination with each other. | miRNA are capable of regulating many RNA and in combination with each other. | ||
One of the first families of miRNA, Let-7, was discovered in ''[[Caenorhabditis elegans|Caenorhabditis | One of the first families of miRNA, Let-7, was discovered in ''[[Caenorhabditis elegans|Caenorhabditis elegans]]. ''Let-7 has since been discovered in humans and is controlled at post-transcriptional level. Misregulation of Let-7 can lead to uncontrolled cell growth and cancer <ref>S. Roush &amp;amp;amp;amp;amp;amp; F.J. Slack, (2008), Trends in Cell Biology, 18(10), 505-516</ref>. | ||
=== References === | === References === | ||
<references /> | <references /> | ||
Latest revision as of 12:27, 25 October 2012
MicroRNAs (miRNA) are non-coding RNA around 22 nucleotides in length. They are responsible for gene expression and preventing translation of mRNA. miRNAs are highly conserved in evolutionary terms [1].
Precursors to miRNA are made by RNA Polymerase II. These precursors are then processed and incorporated into a set of proteins to create an RNA-Induced Silencing Complex [2].
miRNA are capable of regulating many RNA and in combination with each other.
One of the first families of miRNA, Let-7, was discovered in Caenorhabditis elegans. Let-7 has since been discovered in humans and is controlled at post-transcriptional level. Misregulation of Let-7 can lead to uncontrolled cell growth and cancer [3].