Calmodulin

Calcium binding protein involved in intracellular calcium signalling.

Structure

Highly conserved sequence of 152 amino acids

There are four EFh domains which are responsible for Ca2+ binding

Function

Calmodulin binds Ca²⁺ to maintain low cytosolic Ca²⁺ concentration

Two or more Ca²⁺ ions bind to induce a conformational change and activate calmodulin