Parkinson's Disease: Difference between revisions
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Created page with " Parkinson’s disease is an idiopathic and has no known cause. It is normally due to the degeneration of dopaminergic neurones of the nigrostriatal tract and loss of DA neu..." |
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Revision as of 17:00, 19 October 2013
Parkinson’s disease is an idiopathic and has no known cause. It is normally due to the degeneration of dopaminergic neurones of the nigrostriatal tract and loss of DA neurotransmission in the striatum. The symptoms of this disease are a resting tremor, muscle rigidity and suppression of voluntary movements (hypokinesis).
The main 4 dopaminergic pathways are:-
• Nigrostriatal
– Substantia nigra to striatum
• Mesolimbic
– Ventral tegmental area to nucleus accumbens
• Mesocortical
– Ventral tegmental area to frontal cortex
• Tuberoinfundibular
– Arcuate nucleus to pituitary gland
The decarboxylase inhibitor – carbidopa, the MAO inhibitor: Selegiline and D2 receptor agonists like Bromocriptine can be used to treat Parkinson’s disease.