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Created page with " NAPQI (N-acetyl-p-benzoquinone imine) Is a very reactive biproduct of the metabolism of paracetamol via the P-450 system. It is toxic due to it binding to e..." |
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NAPQI (N-acetyl-p-benzoquinone imine) Is a very reactive biproduct of the metabolism of [[Paracetamol|paracetamol]] via the P-450 system. It is toxic due to it binding to essential protiens inside the hepatic cells causing liver damage. | NAPQI (N-acetyl-p-benzoquinone imine) Is a very reactive biproduct of the metabolism of [[Paracetamol|paracetamol]] via the P-450 system. It is toxic due to it binding to essential protiens inside the hepatic cells causing liver damage. | ||
It is produced when levels of [[Glutathione|glutathion]] in the liver cells are low. | It is produced when levels of [[Glutathione|glutathion]] in the liver cells are low <ref>http://www.vetmed.vt.edu/education/Curriculum/VM8304/vet%20pathology/CASES/CELLINJURY2/PAGE3-2.htm</ref>.<br> | ||
=== References === | |||
<references /><br> | |||
Latest revision as of 02:51, 24 October 2014
NAPQI (N-acetyl-p-benzoquinone imine) Is a very reactive biproduct of the metabolism of paracetamol via the P-450 system. It is toxic due to it binding to essential protiens inside the hepatic cells causing liver damage.
It is produced when levels of glutathion in the liver cells are low [1].