Disulphide bridges: Difference between revisions

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A disulphide bridge can also be called a disulphide bond. It is the name of the [[Covalent bond]] that is formed when two thiol groups, SH groups, undergo [[Oxidation]] and a bond forms between the two Sulphur atoms. In the formation of this type of bond, two [[Protons]] and two [[Electron]]s are produced as biproducts.  
Disulphide bridges are [[Covalent bonds|covalent]] sulphur-[[Sulphur|sulphur]] bonds formed by the oxidation of the thiol groups of two [[Cysteine|cysteine]] residues<ref>http://www.cryst.bbk.ac.uk/PPS2/projects/day/TDayDiss/DisulphideBonds.html</ref>.&nbsp;These types of bonds are most commonly found in the tertiary structure of proteins for further folding, and thus to produce a more specific shape for the ultimate funciton of the protein. Disulphide bonds tend not to be formed in intracellular proteins<ref>Moran L, Horton R, Scrimgeour G, Perry M, Principles of Biochemistry, 5th Ed, Essex, Pearson Education Limited, 2014, Page number 144</ref>.<br>


Disulphide bonds are often present in [[Tertiary Protein Structure]]&nbsp;between [[Cysteine]]&nbsp;residues, as they help to stabilise the protein. The S-S bonds are formed as part of the folding of the&nbsp;protein into its final 3D&nbsp;structure in the&nbsp;[[Endoplasmic reticulum]]<ref>http://www.ncbi.nlm.nih.gov/pubmed/10754564</ref>.
=== Reference  ===


The disulphide&nbsp;bonds only occur on the extracellular domains of a protein, as in the [[Cytosol]]&nbsp;(a reducing environment) the bonds become unstable and break.
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Latest revision as of 01:00, 10 December 2018

Disulphide bridges are covalent sulphur-sulphur bonds formed by the oxidation of the thiol groups of two cysteine residues[1]. These types of bonds are most commonly found in the tertiary structure of proteins for further folding, and thus to produce a more specific shape for the ultimate funciton of the protein. Disulphide bonds tend not to be formed in intracellular proteins[2].

Reference

  1. ↑ http://www.cryst.bbk.ac.uk/PPS2/projects/day/TDayDiss/DisulphideBonds.html
  2. ↑ Moran L, Horton R, Scrimgeour G, Perry M, Principles of Biochemistry, 5th Ed, Essex, Pearson Education Limited, 2014, Page number 144


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