Ras pathway: Difference between revisions
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This is a chain reaction between proteins which brings about a cellular response to a stimulus. | This is a chain reaction between proteins which brings about a cellular response to a stimulus. Once a stimulus has attached to a receptor on the cell surface membrane the pathway is driven by [[phosphorylation|phosphorylation]] of proteins in a [[kinase cascade|kinase cascade]] leading to the [[transcription factor|transcription]] of a [[gene|gene]] in the [[nucleus|nucleus]] then [[translation|translation]] of the [[mRNA|mRNA]] into a [[protein|protein]] to change the cell state<ref>Orton RJ, Sturm OE, Vyshemirsky V, Calder M, Gilbert DR, Kolch W (2005) Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway The Biochemical journal 392(2):249–61</ref>. | ||
Once a stimulus has attached to a receptor on the cell surface membrane the pathway is driven by phosphorylation of proteins in a kinase cascade leading to the transcription of a gene in the nucleus then translation of the mRNA into a protein to change the cell state. | |||
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Latest revision as of 02:28, 30 October 2015
This is a chain reaction between proteins which brings about a cellular response to a stimulus. Once a stimulus has attached to a receptor on the cell surface membrane the pathway is driven by phosphorylation of proteins in a kinase cascade leading to the transcription of a gene in the nucleus then translation of the mRNA into a protein to change the cell state[1].
References
- ↑ Orton RJ, Sturm OE, Vyshemirsky V, Calder M, Gilbert DR, Kolch W (2005) Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway The Biochemical journal 392(2):249–61