Post-translation modification: Difference between revisions
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Post-translational modification (PTM) is the process in which a | Post-translational modification (PTM) is the process in which a protein is modified after protein biosynthesis. | ||
PTM is specific and it is mainly catalysed by enzymes.There are many types of modification, such as [[Phosphorylation|phosphorylation]], [[Acetylation|acetylation]], [[Hydroxylation|hydroxylation]] ,[[Hydroxylation|methylation]], [[Glycosylation|glycosylation]], | PTM is specific and it is mainly catalysed by enzymes.There are many types of modification, such as [[Phosphorylation|phosphorylation]], [[Acetylation|acetylation]], [[Hydroxylation|hydroxylation]] ,[[Hydroxylation|methylation]], [[Glycosylation|glycosylation]], AMPylation, lipidation, [[Ubiquitination|ubiquitination]], proteolysis and [[Deamination|deamidation]]<ref>P Surat P. Types of Protein Post-Translational Modification [Internet]. News-Medical.net. 2018 [cited 19 October 2018]. Available from: https://www.news-medical.net/life-sciences/Types-of-Protein-Post-Translational-Modification.aspx</ref>. | ||
PTM is important for cellular functions. It is found to be involved in [[Cell signalling|cell signalling]], protein folding, [[Immune response|immune response]] and protein stability<ref>Theillet, F.-X., Smet-Nocca, C., Liokatis, S., Thongwichian, R., Kosten, J., Yoon, M.-K., … Selenko, P. (2012). Cell | PTM is important for cellular functions. It is found to be involved in [[Cell signalling|cell signalling]], protein folding, [[Immune response|immune response]] and protein stability<ref>Theillet, F.-X., Smet-Nocca, C., Liokatis, S., Thongwichian, R., Kosten, J., Yoon, M.-K., … Selenko, P. (2012). Cell signalling, post-translational protein modifications and NMR spectroscopy. Journal of Biomolecular NMR, 54(3), 217–236. http://doi.org/10.1007/s10858-012-9674-x</ref>. | ||
=== References === | === References === | ||
<references /><br> | <references /><br> | ||
Latest revision as of 06:58, 23 October 2018
Post-translational modification (PTM) is the process in which a protein is modified after protein biosynthesis.
PTM is specific and it is mainly catalysed by enzymes.There are many types of modification, such as phosphorylation, acetylation, hydroxylation ,methylation, glycosylation, AMPylation, lipidation, ubiquitination, proteolysis and deamidation[1].
PTM is important for cellular functions. It is found to be involved in cell signalling, protein folding, immune response and protein stability[2].
References
- ↑ P Surat P. Types of Protein Post-Translational Modification [Internet]. News-Medical.net. 2018 [cited 19 October 2018]. Available from: https://www.news-medical.net/life-sciences/Types-of-Protein-Post-Translational-Modification.aspx
- ↑ Theillet, F.-X., Smet-Nocca, C., Liokatis, S., Thongwichian, R., Kosten, J., Yoon, M.-K., … Selenko, P. (2012). Cell signalling, post-translational protein modifications and NMR spectroscopy. Journal of Biomolecular NMR, 54(3), 217–236. http://doi.org/10.1007/s10858-012-9674-x