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Proinsulin is the precursor to insulin. It is synthesised by the pancreas within the cells which make up the the | Proinsulin is the precursor to [[insulin|insulin]]. It is synthesised by the [[pancreas|pancreas]] within the cells which make up the the [[Islets of Langerhans|Islets of Langerhans]]. Proinsulin is formed from [[pre-proinsulin|pre-proinsulin]] when the [[signal peptide|signal peptide]] is cleaved off, and successively mature insulin is formed when the [[C peptide|C peptide]] is cleaved via [[endoproteases|endoproteases]] from proinsulin<ref>https://en.wikipedia.org/wiki/Proinsulin</ref>. | ||
Without proinsulin insulin would not be able to be | Without proinsulin, insulin would not be able to be generated which would cause a wide range of disorders and illnesses within humans. <br> | ||
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Latest revision as of 10:06, 8 December 2018
Proinsulin is the precursor to insulin. It is synthesised by the pancreas within the cells which make up the the Islets of Langerhans. Proinsulin is formed from pre-proinsulin when the signal peptide is cleaved off, and successively mature insulin is formed when the C peptide is cleaved via endoproteases from proinsulin[1].
Without proinsulin, insulin would not be able to be generated which would cause a wide range of disorders and illnesses within humans.