P21: Difference between revisions
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P21 is an example of a cyclin-dependent kinase inhibitor (CKI). P21 protein inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4/6 complexes, and therefore functions acts as a modulator of cell cycle in turn determining wheteher progression at G1 and S phase will occur. | P21 is an example of a [[Cyclin-dependent kinase|cyclin-dependent kinase]] inhibitor (CKI). P21 protein inhibits the activity of [[Cyclin-CDK2|cyclin-CDK2]], [[Cyclin-CDK1|-C]][[Cyclin-CDK1|DK1]], and [[Cyclin-CDK4/6|-CDK4/6]] complexes, and therefore functions acts as a modulator of [[Cell cycle|cell cycle]] in turn determining wheteher progression at G1 and S phase will occur<ref>Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ (November 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805–16. doi:10.1016/0092-8674(93)90499-G. PMID 8242751</ref>. | ||
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Latest revision as of 09:17, 10 December 2018
P21 is an example of a cyclin-dependent kinase inhibitor (CKI). P21 protein inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4/6 complexes, and therefore functions acts as a modulator of cell cycle in turn determining wheteher progression at G1 and S phase will occur[1].
References
- ↑ Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ (November 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805–16. doi:10.1016/0092-8674(93)90499-G. PMID 8242751