From The School of Biomedical Sciences Wiki
Jump to navigation
Jump to search
|
|
| Line 1: |
Line 1: |
| Acetyl CoA (Acetyl coenzyme A) is a vital [[molecule|molecule]] which is needed in [[metabolism|metabolism]]. It's job is to transport 2 carbon atoms, using a high-energy linkage, in biosynthesis of a larger molecule(s)<ref>Bruce Alberts (2008). Molecular Biology of the Cell. New York: Garland Science. p83-84.</ref>. The rest of the [[molecule|molecule]] is used as a recognition site for specific [[enzymes|enzymes]]. <br>Acetyl CoA is used at the start the [[Krebs_cycle|Kreb's cycle]] ([[Krebs_cycle|Citric Cycle]]) where it is the product of the binding of [[CoA|CoA]] and [[pyruvate|pyruvate]]. This conversion of [[pyruvate|pyruvate]] into acetyl CoA consists of three steps: [[decarboxylation|decarboxylation]], [[Oxidation|oxidation]], and transfer of the resultant [[acetyl group|acetyl group]] to [[CoA|CoA]]<ref>Stryer, L., Berg, J. M. &amp;amp;amp; Tymoczko, J. L., 2002. Biochemistry. 5th ed. : W.H.Freeman &amp;amp;amp; Co Ltd.</ref>. The acetyl group then is transferred to [[oxaloacetate|oxaloacetate]] which forms [[citric acid|citric acid]], by the reaction of [[oxaloacetate|oxaloacetate]] with acetyl CoA and [[water|water]], which then goes through a a series of oxidations to produce energy rich activated carrier [[molecules|molecules]]. It can also be fed directly into the [[Krebs_cycle|Kreb's cycle]] via [[beta-oxidation|beta-oxidation]], where [[fatty acid|fatty acids]] are oxidised into qcetyl CoA, the process is carried out in [[Peroxisomes|peroxisomes]] and the resulting Acetyl CoA is expelled into [[Cytosol|cytosol]]. <br>
| | See [[Acetyl_CoA|Acetyl CoA]] |
| | |
| === References<br> ===
| |
| | |
| <references /><br>
| |
Latest revision as of 00:21, 28 November 2013