Premature Stop Codon: Difference between revisions
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A Premature Stop [[Codon|Codon]] is a sequence [[Mutation|mutation]] type (such as a [[Frameshift Mutation|Frameshift Mutation]]) that results in the coding of a Stop [[Codon|Codon]] prematurely in the [[Reading frame|reading frame]]. <br> | |||
A Premature Stop [[Codon|Codon]] is a sequence [[Mutation|mutation]] type ( | |||
== Frequency == | |||
Premature Stop Codons are common in sequence mutations as 3 out of the 64 Codons in the Universal Codon Code programme for a Stop Codon. Coupling this with the often random nature of sequence mutations, this generates an average Premature Stop Codon creation of 1 in every 20 Codon mutations, a very common frequency within the already small Mutation Frequency of even simple Prokaryotic life, let alone higher Eukaryotes. | Premature Stop Codons are common in sequence mutations as 3 out of the 64 Codons in the Universal Codon Code programme for a Stop Codon. Coupling this with the often random nature of sequence mutations, this generates an average Premature Stop Codon creation of 1 in every 20 Codon mutations, a very common frequency within the already small Mutation Frequency of even simple Prokaryotic life, let alone higher Eukaryotes. | ||
== Consequences of Premature Stop Codons == | == Consequences of Premature Stop Codons == | ||
The addition of an unwanted Stop Codon cuts a Ribosome's process of Polypeptide Synthesis along an | The addition of an unwanted Stop Codon cuts a [[Ribosome|Ribosome's]] process of Polypeptide Synthesis along an [[MRNA|mRNA]] Strangd short, resulting in fragmented incomplete [[Polypeptide|Polypeptide]] strands. These fragmented Polypeptide strands do not undergo succesful structural folding to form the appropriate [[Secondary structure|Secondary]], [[Tertiary structure|Tertiary]] and even [[Quaternary Structure|Quaternary Structures]] of the originally-intented [[Protein|Protein]], typically creating stumped or Truncated Proteins which often affects the function of the [[Proteins|protein]] by various pathways. | ||
Latest revision as of 18:50, 13 November 2011
A Premature Stop Codon is a sequence mutation type (such as a Frameshift Mutation) that results in the coding of a Stop Codon prematurely in the reading frame.
Frequency
Premature Stop Codons are common in sequence mutations as 3 out of the 64 Codons in the Universal Codon Code programme for a Stop Codon. Coupling this with the often random nature of sequence mutations, this generates an average Premature Stop Codon creation of 1 in every 20 Codon mutations, a very common frequency within the already small Mutation Frequency of even simple Prokaryotic life, let alone higher Eukaryotes.
Consequences of Premature Stop Codons
The addition of an unwanted Stop Codon cuts a Ribosome's process of Polypeptide Synthesis along an mRNA Strangd short, resulting in fragmented incomplete Polypeptide strands. These fragmented Polypeptide strands do not undergo succesful structural folding to form the appropriate Secondary, Tertiary and even Quaternary Structures of the originally-intented Protein, typically creating stumped or Truncated Proteins which often affects the function of the protein by various pathways.