Multi-drug resistance (MDR): Difference between revisions

Latest revision as of 13:10, 23 October 2017

Multi-drug resistance is a condition where cancer cells are resistant to chemotherapy drugs due to the presence on a drug eflux pump called the p-glycoprotein that actively pumps out drugs from the cell. P-glycoprotein in normal gut epithelial cells help to expell toxic substances in the food we eat, but this is up-regulated in cancer cells. The p-glycoprotein is part of the ABC transporter superfamily. Also see Antibiotic Resistance.

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	Multi-drug resistance is a condition where cancer cells are resistant to chemotherapy drugs due to the presence on a drug eflux pump called the [[P-glycoprotein\|p-glycoprotein]] that actively pumps out drugs from the cell. P-glycoprotein in normal [[~~Epithelial_cells~~\|epithelial cells]] help to expell toxic substances in the food we eat, but this is up-regulated in cancer cells. The p-[[~~glycoprotein~~\|glycoprotein]] is part of the [[ABC transporter superfamily\|ABC transporter superfamily]].		Multi-drug resistance is a condition where [[Cancer\|cancer]] cells are resistant to [[Chemotherapy\|chemotherapy]] drugs due to the presence on a drug eflux pump called the [[P-glycoprotein\|p-glycoprotein]] that actively pumps out drugs from the cell. [[P-glycoprotein\|P-glycoprotein]] in normal gut [[Epithelial cells\|epithelial cells]] help to expell toxic substances in the food we eat, but this is up-regulated in [[Cancer\|cancer]] cells. The p-[[Glycoprotein\|glycoprotein]] is part of the [[ABC transporter superfamily\|ABC transporter superfamily]]. Also see [[Antibiotic_resistance\|Antibiotic Resistance]].