B-cells: Difference between revisions
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B cells are a major part of the body's immune system. They start off as [[Lymphocyte|lymphocytes ]] | B cells are a major part of the body's immune system. They start off as [[Lymphocyte|lymphocytes and]] are then given their specific function inside the [[Bone marrow|bone marrow]]. B cells work alongside [[T cells|T cells]] to protect the body from [[Pathogens|pathogens]]. When a pathogen enters the body, B and T cells leave the blood circulation and enter the [[Lymph nodes|lymph nodes where]] the [[Adaptive immune response|adaptive immune response is]] intiated. The [[Antigen|antigens]] of the pathogen enter the lyph node as a soluble antigen or carried by [[Dendritic cells|denditic cells]]. B cells are antigen presenting cells and interact with the soluble antigens. B cells are partially activated when a soluble antigen belonging to a pathogen interacts with it's [[Receptors|receptor]]. The B cell engulfs the antigen by [[Endocytosis|endocytosis]] and then presents the antigen on it's own membrane. T cells then interact with these antigen presenting B cells via their T cell receptors. Once this happens the B cells are fully activated and proliferate into [[Plasma cells|plasma cells]] and B memory cells. Plasma cells then secrete [[Antibodies|antibodies that]] recognise pathogens that have the specific antigen presented by the B cells previously. The B memory cells remain behind in case a second infection by the same pathogen attacks the body<ref>H. Lodish, A. Berk, C. Kaiser, M. Krieger, M. Scott, A. Bretscher, H. Ploegh, P. Matsudaira (2007) Molecular Cell Biology, 6th edition, New York: W.H Freeman and Company. Chapter 24 Pages 1057-1058, 1099-1101, 1061</ref>. <br> | ||
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Latest revision as of 16:39, 23 November 2018
B cells are a major part of the body's immune system. They start off as lymphocytes and are then given their specific function inside the bone marrow. B cells work alongside T cells to protect the body from pathogens. When a pathogen enters the body, B and T cells leave the blood circulation and enter the lymph nodes where the adaptive immune response is intiated. The antigens of the pathogen enter the lyph node as a soluble antigen or carried by denditic cells. B cells are antigen presenting cells and interact with the soluble antigens. B cells are partially activated when a soluble antigen belonging to a pathogen interacts with it's receptor. The B cell engulfs the antigen by endocytosis and then presents the antigen on it's own membrane. T cells then interact with these antigen presenting B cells via their T cell receptors. Once this happens the B cells are fully activated and proliferate into plasma cells and B memory cells. Plasma cells then secrete antibodies that recognise pathogens that have the specific antigen presented by the B cells previously. The B memory cells remain behind in case a second infection by the same pathogen attacks the body[1].
References
- ↑ H. Lodish, A. Berk, C. Kaiser, M. Krieger, M. Scott, A. Bretscher, H. Ploegh, P. Matsudaira (2007) Molecular Cell Biology, 6th edition, New York: W.H Freeman and Company. Chapter 24 Pages 1057-1058, 1099-1101, 1061