G-protein: Difference between revisions
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In [[Cell signalling pathways|signalling pathways]], G-proteins act as transducers and convert signals from one form to another form, by binding to other proteins in the plasma membrane of a cell. They can bind [[GTP|GTP]] or [[GDP|GDP]]. G-proteins can be either trimeric or monomeric. Monomeric G-proteins transduce signals from [[Enzyme-coupled Receptor|enzyme-linked receptors]] whereas trimeric G-proteins transduce signals from [[G-protein Coupled Receptor|G-protein linked receptors]] <ref name="[1]">B Alberts et al. (2008) Molecular Biology of the Cell, 5th Edition, New York:Garland Science</ref>. [[Ion channels|Ion channels]] can be activated by binding of G-proteins. This can slow the heart beat when G-proteins bind to [[ | In [[Cell signalling pathways|signalling pathways]], G-proteins act as transducers and convert signals from one form to another form, by binding to other proteins in the plasma membrane of a cell. They can bind [[GTP|GTP]] or [[GDP|GDP]]. G-proteins can be either trimeric or monomeric. Monomeric G-proteins transduce signals from [[Enzyme-coupled Receptor|enzyme-linked receptors]] whereas trimeric G-proteins transduce signals from [[G-protein Coupled Receptor|G-protein linked receptors]] <ref name="[1]">B Alberts et al. (2008) Molecular Biology of the Cell, 5th Edition, New York:Garland Science</ref>. [[Ion channels|Ion channels]] can be activated by binding of G-proteins. This can slow the heart beat when G-proteins bind to [[Muscarinic receptors|muscarinic receptors]], as they increase the permeability of a neurone to K<sup>+</sup> ions, which decreases the rate of neurone firing <ref>Purves D, Augustine GJ, Fitzpatrick D, et al (2001) Neuroscience (2nd ed.) Sunderland MA: Sinauer Associates</ref>. <br> | ||
=== References === | === References === | ||
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Revision as of 00:52, 24 October 2014
In signalling pathways, G-proteins act as transducers and convert signals from one form to another form, by binding to other proteins in the plasma membrane of a cell. They can bind GTP or GDP. G-proteins can be either trimeric or monomeric. Monomeric G-proteins transduce signals from enzyme-linked receptors whereas trimeric G-proteins transduce signals from G-protein linked receptors [1]. Ion channels can be activated by binding of G-proteins. This can slow the heart beat when G-proteins bind to muscarinic receptors, as they increase the permeability of a neurone to K+ ions, which decreases the rate of neurone firing [2].