Vesicles: Difference between revisions
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Vesicles are intracellular transporters, used to move macromolecules around the cell. A vesicle is made when an invaginated [[Membrane|membrane]] part buds off from an organelle.This [[Organelle|organelle is]] usually the the [[Golgi Apparatus|Golgi Apparatus]]; vesicles bud from the 'trans' end. Vesicles are vital to processes of intracellular transport, such as endo- and [[Exocytosis|exocytosis]]. Vesicles have the ability to release or expel thier contents on reaching and fusing to the plasma membrane. For example, vesicles transport acetylcholine to the pre-synaptic membrane of a neuronal cell, where it is released into the [[Excitatory postsynaptic potential|synaptic cleft]], to be received at the post-synaptic membrane. Vesicles are coated in protein. Different protein coats aid different | Vesicles are intracellular transporters, used to move macromolecules around the cell. A vesicle is made when an invaginated [[Membrane|membrane]] part buds off from an organelle.This [[Organelle|organelle is]] usually the the [[Golgi Apparatus|Golgi Apparatus]]; vesicles bud from the 'trans' end. Vesicles are vital to processes of intracellular transport, such as endo- and [[Exocytosis|exocytosis]]. Vesicles have the ability to release or expel thier contents on reaching and fusing to the plasma membrane. For example, vesicles transport acetylcholine to the pre-synaptic membrane of a neuronal cell, where it is released into the [[Excitatory postsynaptic potential|synaptic cleft]], to be received at the post-synaptic membrane. Vesicles are coated in [[Protein structure|protein]]. Different protein coats aid different transport steps.<ref name="null">Alberts B., Johnson A., Lewis J., Raff M., Roberts K., Walter P (2007:754) Molecular Biology of the Cell, 5th edition, New York: Garland Science</ref> Among the great variety of protein coats is Clathrin. A vesicle's Clathrin coat can partly determine its destination, as the coat influences the selection of molecules for transport.<ref>Alberts B, Johnson A, Lewis J, Raff M, Roberts K and Walter P (2007:751) Molecular Biology of the Cell, 5th edition, New York: Garland Science</ref> A vesicle's destination is also influenced by two other proteins, Rab proteins and SNAREs. Rab proteins are responsible for getting the vesicle to the correct location on a specific membrane. The SNARE proteins guide the docking of the vesicle onto the required organelle. <ref>Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2007:760) Molecular Biology of the Cell, 5th edition, New York, Garland Science</ref> V-SNAREs release vesicles from the donor organelle and the T-SNAREs guide vesicles to the receptor organelle. | ||
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Revision as of 17:47, 26 November 2010
Vesicles are intracellular transporters, used to move macromolecules around the cell. A vesicle is made when an invaginated membrane part buds off from an organelle.This organelle is usually the the Golgi Apparatus; vesicles bud from the 'trans' end. Vesicles are vital to processes of intracellular transport, such as endo- and exocytosis. Vesicles have the ability to release or expel thier contents on reaching and fusing to the plasma membrane. For example, vesicles transport acetylcholine to the pre-synaptic membrane of a neuronal cell, where it is released into the synaptic cleft, to be received at the post-synaptic membrane. Vesicles are coated in protein. Different protein coats aid different transport steps.[1] Among the great variety of protein coats is Clathrin. A vesicle's Clathrin coat can partly determine its destination, as the coat influences the selection of molecules for transport.[2] A vesicle's destination is also influenced by two other proteins, Rab proteins and SNAREs. Rab proteins are responsible for getting the vesicle to the correct location on a specific membrane. The SNARE proteins guide the docking of the vesicle onto the required organelle. [3] V-SNAREs release vesicles from the donor organelle and the T-SNAREs guide vesicles to the receptor organelle.
References
- ↑ Alberts B., Johnson A., Lewis J., Raff M., Roberts K., Walter P (2007:754) Molecular Biology of the Cell, 5th edition, New York: Garland Science
- ↑ Alberts B, Johnson A, Lewis J, Raff M, Roberts K and Walter P (2007:751) Molecular Biology of the Cell, 5th edition, New York: Garland Science
- ↑ Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2007:760) Molecular Biology of the Cell, 5th edition, New York, Garland Science