GTPase: Difference between revisions
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== <u>'''Overview'''</u> == | == <u>'''Overview'''</u> == | ||
GTPases are a group of [[Enzyme|enzymes]] which hydrolyse [[GTP|GTP]] to [[GDP|GDP]] (a [[Phosphate|phosphate]] group is removed). They play an important roll in [[Cell signalling|cell signalling]] pathways for example, GTP/GDP bound [[G-proteins|G proteins]] have intrinsic GTPase activity to slowly reset themselves to their resting state state once it has fullfilled its function <ref>Berg J, Tymoczko J and Stryer L, 2007. Biochemistry, 6th Edition, New York: W.H.Freeman &amp;amp;amp;amp; Co Ltd. (page 387)</ref>. They are also involved in the synthesis of [[Proteins|proteins]] at the [[Ribosomes|Ribosome]] <ref>Berg J, Tymoczko J and Stryer L, 2007. Biochemistry, 6th Edition, New York: W.H.Freeman &amp;amp;amp; Co Ltd. (page 881)</ref>. They also have roles in [[Vesicle|vesicle]] movement and [[ | GTPases are a group of [[Enzyme|enzymes]] which hydrolyse [[GTP|GTP]] to [[GDP|GDP]] (a [[Phosphate|phosphate]] group is removed). They play an important roll in [[Cell signalling|cell signalling]] pathways for example, GTP/GDP bound [[G-proteins|G proteins]] have intrinsic GTPase activity to slowly reset themselves to their resting state state once it has fullfilled its function <ref>Berg J, Tymoczko J and Stryer L, 2007. Biochemistry, 6th Edition, New York: W.H.Freeman &amp;amp;amp;amp;amp; Co Ltd. (page 387)</ref> (Please note not all G proteins have an active intrinsic GTPase activity and require association with GAP (GTPase activating proteins) in order to hydrolyse GTP). They are also involved in the synthesis of [[Proteins|proteins]] at the [[Ribosomes|Ribosome]] <ref>Berg J, Tymoczko J and Stryer L, 2007. Biochemistry, 6th Edition, New York: W.H.Freeman &amp;amp;amp;amp; Co Ltd. (page 881)</ref>. They also have roles in [[Vesicle|vesicle]] movement and [[Cell division|cell division]]. | ||
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Revision as of 14:26, 25 November 2011
Overview
GTPases are a group of enzymes which hydrolyse GTP to GDP (a phosphate group is removed). They play an important roll in cell signalling pathways for example, GTP/GDP bound G proteins have intrinsic GTPase activity to slowly reset themselves to their resting state state once it has fullfilled its function [1] (Please note not all G proteins have an active intrinsic GTPase activity and require association with GAP (GTPase activating proteins) in order to hydrolyse GTP). They are also involved in the synthesis of proteins at the Ribosome [2]. They also have roles in vesicle movement and cell division.