Dosage Compensation Mechanism: Difference between revisions
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< | Mechanism by which [[X chromosome|X chromosome]] levels are re-established to levels seen in males. Such a mechanism only exists in females therefore. Dosage compensation requires [[RNA polymerase|RNA polymerase]], [[Tsix transcript|Tsix transcript]] and [[Xist transcript|Xist transcript]] as well as the X chromosomes of developing embryonic cells. Note that each transcript is transcribed on one [[chromosome|chromosome]] each. Xist acts as to ensure inactivation of X chromosome whereas Tsix ensures X chromosome remains active. Such activity is carried out from the [[X inactivation centre|X inactivation centre]].<ref>Lodish, et al. 2008. (Molecular Cell Biology) 6th edition. pg 959 Fig22-7</ref> | ||
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Revision as of 09:53, 27 November 2011
Mechanism by which X chromosome levels are re-established to levels seen in males. Such a mechanism only exists in females therefore. Dosage compensation requires RNA polymerase, Tsix transcript and Xist transcript as well as the X chromosomes of developing embryonic cells. Note that each transcript is transcribed on one chromosome each. Xist acts as to ensure inactivation of X chromosome whereas Tsix ensures X chromosome remains active. Such activity is carried out from the X inactivation centre.[1]
References
- ↑ Lodish, et al. 2008. (Molecular Cell Biology) 6th edition. pg 959 Fig22-7