X chromosome Inactivation: Difference between revisions
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To establish equal levels of expressed genes between males and females, a mechanism known as dosage compensation is necessary. In mammals this process is called X chromsome inactivation.<br> | To establish equal levels of expressed genes between males and females, a mechanism known as dosage compensation is necessary. In mammals this process is called X chromsome inactivation.<br> | ||
X chromosome inactivation occurs in mammals with two or more X chromosomes. In a normal female, there are two [[X chromosome|X chromosomes]] and in a normal male there is an X chromosome and a Y chromosome. The X chromosome contains about 1000 genes and is much larger than the Y chromosome that contains less than 100 genes. | X chromosome inactivation occurs in mammals with two or more X chromosomes. In a normal female, there are two [[X chromosome|X chromosomes]] and in a normal male there is an X chromosome and a Y chromosome. The X chromosome contains about 1000 genes and is much larger than the Y chromosome that contains less than 100 genes.<ref>Alberts, B. et al., 2008. Molecular Biology of The Cell. 5th ed. New York: Garland Science. p 473</ref> | ||
Since females have two X chromosomes, it contains significantly more genes than males. To establish equal levels of expressed genes between males and females, a mechanism known as dosage compensation is necessary. In mammals dosage compensation is achieved by X chromosome inactivation. | Since females have two X chromosomes, it contains significantly more genes than males. To establish equal levels of expressed genes between males and females, a mechanism known as dosage compensation is necessary. In mammals dosage compensation is achieved by X chromosome inactivation. | ||
During the process of X chromosome activation, one of the two X chromosomes, in each cell becomes highly condensed into a structure known as barr body.<ref>Alberts, B. et al., 2008. Molecular Biology of The Cell. 5th ed. New York: Garland Science. p473</ref> This process takes place in all embryos and the choice of whether to inactivate the paternally or maternally inherited X chromosome is generally random. (With the exception of marsupial mammals like the kangaroo, the koala and the wombat where X chromosome that is inactivated is always the paternally inherited one.<ref>Hartyl, D.L. and Ruvolo, M., 2011. Genetics Analysis of Genes and Genomes. 8th ed. London: Jones &amp; Bartlett Learning International. p264</ref> Once one of the X chromosomes is inactivated, the same one is inactivated in all preceding cell divisions of that cell and its progeny. Although X chromosome inactivation is permanent, there is an exception where the process is reversed during germ line cell formation. Therefore all haploid cell in ovary that may undergo meiosis will contain an active X-chromosome.<br> <br>X chromosome inactivation allows two X chromosomes to be present in the nucleus. It is initiated and spread from a site in middle of chromosome called the X-inactivation center (XIC). An RNA molecule, XIST RNA, is expressed only from the inactive X chromosome and will remain in the nucleus, coating the entire inactive X chromosome with [[Heterochromatin|heterochromatin]] which results in gene silencing. About 10% of the genes on the X-chromosome escape this silencing and remain active. X chromosomes lacking XIC will not be inactivated and will cause organism to die. | During the process of X chromosome activation, one of the two X chromosomes, in each cell becomes highly condensed into a structure known as barr body.<ref>Alberts, B. et al., 2008. Molecular Biology of The Cell. 5th ed. New York: Garland Science. p473</ref> This process takes place in all embryos and the choice of whether to inactivate the paternally or maternally inherited X chromosome is generally random. (With the exception of marsupial mammals like the kangaroo, the koala and the wombat where X chromosome that is inactivated is always the paternally inherited one.<ref>Hartyl, D.L. and Ruvolo, M., 2011. Genetics Analysis of Genes and Genomes. 8th ed. London: Jones &amp;amp;amp; Bartlett Learning International. p264</ref> Once one of the X chromosomes is inactivated, the same one is inactivated in all preceding cell divisions of that cell and its progeny. Although X chromosome inactivation is permanent, there is an exception where the process is reversed during germ line cell formation. Therefore all haploid cell in ovary that may undergo meiosis will contain an active X-chromosome.<br> <br>X chromosome inactivation allows two X chromosomes to be present in the nucleus. It is initiated and spread from a site in middle of chromosome called the X-inactivation center (XIC). An RNA molecule, XIST RNA, is expressed only from the inactive X chromosome and will remain in the nucleus, coating the entire inactive X chromosome with [[Heterochromatin|heterochromatin]] which results in gene silencing. About 10% of the genes on the X-chromosome escape this silencing and remain active. X chromosomes lacking XIC will not be inactivated and will cause organism to die.<ref>Alberts, B. et al., 2008. Molecular Biology of The Cell. 5th ed. New York: Garland Science. p 474</ref> | ||
<br>X chromosome inactivation has been widely researched, including with mouse [[X chromosome|X chromosomes]]. | <br>X chromosome inactivation has been widely researched, including with mouse [[X chromosome|X chromosomes]]. | ||
Revision as of 02:53, 27 November 2011
To establish equal levels of expressed genes between males and females, a mechanism known as dosage compensation is necessary. In mammals this process is called X chromsome inactivation.
X chromosome inactivation occurs in mammals with two or more X chromosomes. In a normal female, there are two X chromosomes and in a normal male there is an X chromosome and a Y chromosome. The X chromosome contains about 1000 genes and is much larger than the Y chromosome that contains less than 100 genes.[1]
Since females have two X chromosomes, it contains significantly more genes than males. To establish equal levels of expressed genes between males and females, a mechanism known as dosage compensation is necessary. In mammals dosage compensation is achieved by X chromosome inactivation.
During the process of X chromosome activation, one of the two X chromosomes, in each cell becomes highly condensed into a structure known as barr body.[2] This process takes place in all embryos and the choice of whether to inactivate the paternally or maternally inherited X chromosome is generally random. (With the exception of marsupial mammals like the kangaroo, the koala and the wombat where X chromosome that is inactivated is always the paternally inherited one.[3] Once one of the X chromosomes is inactivated, the same one is inactivated in all preceding cell divisions of that cell and its progeny. Although X chromosome inactivation is permanent, there is an exception where the process is reversed during germ line cell formation. Therefore all haploid cell in ovary that may undergo meiosis will contain an active X-chromosome.
X chromosome inactivation allows two X chromosomes to be present in the nucleus. It is initiated and spread from a site in middle of chromosome called the X-inactivation center (XIC). An RNA molecule, XIST RNA, is expressed only from the inactive X chromosome and will remain in the nucleus, coating the entire inactive X chromosome with heterochromatin which results in gene silencing. About 10% of the genes on the X-chromosome escape this silencing and remain active. X chromosomes lacking XIC will not be inactivated and will cause organism to die.[4]
X chromosome inactivation has been widely researched, including with mouse X chromosomes.
- ↑ Alberts, B. et al., 2008. Molecular Biology of The Cell. 5th ed. New York: Garland Science. p 473
- ↑ Alberts, B. et al., 2008. Molecular Biology of The Cell. 5th ed. New York: Garland Science. p473
- ↑ Hartyl, D.L. and Ruvolo, M., 2011. Genetics Analysis of Genes and Genomes. 8th ed. London: Jones &amp;amp; Bartlett Learning International. p264
- ↑ Alberts, B. et al., 2008. Molecular Biology of The Cell. 5th ed. New York: Garland Science. p 474