Trisomy: Difference between revisions
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Trisomy is where there is an extra of a particular [[ | A Trisomy is a type of polysomy inwhich instead of the usual two [[Chromosomes|chromosomes]], there are three copies of a particular chromosome. A trisomy is a type of [[Aneuploidy|aneuploidy]] (an abnormal number of chromosomes). | ||
The majority of human trisomies result in miscarriage, however there are a number of types that survive to birth. These include; [[Trisomy 13|Trisomy 13]] ([[Patau Syndrome|Patau Syndrome]]), [[Trisomy 18|Trisomy 18]] ([[Edward's Syndrome|Edward's syndrome]]) and [[Trisomy 21|Trisomy 21]] ([[Down Syndrome|Down Syndrome]]). Autosomal trisomy shows various levels of mental retardation and is associated with physical traits. | |||
Trisomy of [[Sex chromosomes|sex chromosomes]] also occurs. XXX ([[Triple X syndrome|Triple X syndrome]]) and XXY ([[Klinefelter syndrome|Klinefelter syndrome]]). | |||
Trisomy is where there is an extra of a particular [[Chromosome|chromosome]] due to [[Non disjunction|nondisjunction]] during [[Meiosis|meiosis]]. Trisomy often leads to miscarriage although there are a number of chromosomal abnormalities in which the foetus survives, mainly 13, 18, 21, X and Y. The chance of trisomy occuring increases with the age of the mother. | |||
Main non-lethal trisomies in humans: | Main non-lethal trisomies in humans: | ||
*13-[[Patau Syndrome|Patau Syndrome]] | *13-[[Patau Syndrome|Patau Syndrome]] | ||
*[[Patau Syndrome|Patau Syndrome]]18-[[Edward's Syndrome|Edward's Syndrome]] | *[[Patau Syndrome|Patau Syndrome]]18-[[Edward's Syndrome|Edward's Syndrome]] | ||
*21-[[Down's Syndrome|Down's Syndrome]]<ref>http://downsyndrome.about.com/od/whatcausesdownsyndrome/a/othtrisomies_ro.htm</ref> | *21-[[Down's Syndrome|Down's Syndrome]]<ref>http://downsyndrome.about.com/od/whatcausesdownsyndrome/a/othtrisomies_ro.htm</ref> | ||
*[[X-Triplo|X-Triplo]] x or [[Trisomy X|Trisomy X]] | *[[X-Triplo|X-Triplo]] x or [[Trisomy X|Trisomy X]] | ||
*Y- [[ | *Y- [[Klinefelter syndrome|Klinefelter]] | ||
Occassionally you can also get a tetrasomy in which there are four copies of a chromosome insteasd of two. | Occassionally you can also get a tetrasomy in which there are four copies of a chromosome insteasd of two. | ||
Revision as of 03:09, 27 November 2013
A Trisomy is a type of polysomy inwhich instead of the usual two chromosomes, there are three copies of a particular chromosome. A trisomy is a type of aneuploidy (an abnormal number of chromosomes).
The majority of human trisomies result in miscarriage, however there are a number of types that survive to birth. These include; Trisomy 13 (Patau Syndrome), Trisomy 18 (Edward's syndrome) and Trisomy 21 (Down Syndrome). Autosomal trisomy shows various levels of mental retardation and is associated with physical traits.
Trisomy of sex chromosomes also occurs. XXX (Triple X syndrome) and XXY (Klinefelter syndrome).
Trisomy is where there is an extra of a particular chromosome due to nondisjunction during meiosis. Trisomy often leads to miscarriage although there are a number of chromosomal abnormalities in which the foetus survives, mainly 13, 18, 21, X and Y. The chance of trisomy occuring increases with the age of the mother.
Main non-lethal trisomies in humans:
- 13-Patau Syndrome
- Patau Syndrome18-Edward's Syndrome
- 21-Down's Syndrome[1]
- X-Triplo x or Trisomy X
- Y- Klinefelter
Occassionally you can also get a tetrasomy in which there are four copies of a chromosome insteasd of two.