Amyloidosis: Difference between revisions
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Amyloid fibrils are polymers of identical proteins. When functional, they are beneficial to long-term memory formation and release of peptide hormones.<ref>Amyloid assembly and disassemblyfckLREdward Chuang, Acacia M. Hori, Christina D. Hesketh, James ShorterfckLRJ Cell Sci 2018 131: jcs189928 doi: 10.1242/jcs.189928 Published 13 April 2018</ref> However, issues with amyloid assembly can lead to the formation of abnormal (<span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); font-family: sans-serif; font-size: 13.26px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; line-height: 19.9px; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">misfolded) </span>proteins. This aggregation of pathogenic amyloids is amyloidosis. It happens in various [[Organ|organs]] and [[Tissue|tissues]]. There are many sub classes of amyloidosis. Some amyloid fibrils are pathogens in diseases such as Alzheimer's disease and Parkinson's disease.<ref>Amyloid assembly and disassemblyfckLREdward Chuang, Acacia M. Hori, Christina D. Hesketh, James ShorterfckLRJ Cell Sci 2018 131: jcs189928 doi: 10.1242/jcs.189928 Published 13 April 2018</ref><br> | |||
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Revision as of 15:38, 19 October 2018
Amyloid fibrils are polymers of identical proteins. When functional, they are beneficial to long-term memory formation and release of peptide hormones.[1] However, issues with amyloid assembly can lead to the formation of abnormal (misfolded) proteins. This aggregation of pathogenic amyloids is amyloidosis. It happens in various organs and tissues. There are many sub classes of amyloidosis. Some amyloid fibrils are pathogens in diseases such as Alzheimer's disease and Parkinson's disease.[2]
- ↑ Amyloid assembly and disassemblyfckLREdward Chuang, Acacia M. Hori, Christina D. Hesketh, James ShorterfckLRJ Cell Sci 2018 131: jcs189928 doi: 10.1242/jcs.189928 Published 13 April 2018
- ↑ Amyloid assembly and disassemblyfckLREdward Chuang, Acacia M. Hori, Christina D. Hesketh, James ShorterfckLRJ Cell Sci 2018 131: jcs189928 doi: 10.1242/jcs.189928 Published 13 April 2018