G-proteins: Difference between revisions
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[[Guanine nucleotide|Guanine nucleotide]] binding [[Protein|protein]] that binds [[GTP|GTP]] when activated, which it hydrolyses to [[GDP|GDP]]. The active form of the [[Protein|protein]] can interact with a number of down stream effectors such as [[Adenylyl cyclase|adenylyl cyclase]] (producing [[CAMP|cAMP]] from [[ATP|ATP]]), and [[Phospholipase C|phospholipase C]] ([[PLC|PLC]]). | [[Guanine nucleotide|Guanine nucleotide]] binding [[Protein|protein]] that binds [[GTP|GTP]] when activated, which it hydrolyses to [[GDP|GDP]]. The active form of the [[Protein|protein]] can interact with a number of down stream effectors such as [[Adenylyl cyclase|adenylyl cyclase]] (producing [[CAMP|cAMP]] from [[ATP|ATP]]), and [[Phospholipase C|phospholipase C]] ([[PLC|PLC]]). | ||
The [[G-proteins|G-proteins]] can be divided in to two families - the [[Heterotrimeric G-proteins|heterotrimeric G-proteins]] and the small or [[Mono-meric G-proteins|mono-meric G-proteins]].<br> | The [[G-proteins|G-proteins]] can be divided in to two families - the [[Heterotrimeric G-proteins|heterotrimeric G-proteins]] and the small or [[Mono-meric G-proteins|mono-meric G-proteins]].<br> | ||
G-protein coupled receptors ([[GPCR|GPCR]]) upon binding of [[Stimulus|stimulus]] activates G-protein. | G-protein coupled receptors ([[GPCR|GPCR]]) upon binding of [[Stimulus|stimulus]] activates G-protein. | ||
The structure of a [[GPCR|GPCR ]]shows 7 transmembrane spans, with 3 exoloops and 4 cytoloops. The N-terminal is found on the outside of the membrane and the C-terminal found on the cytosolic side of the membrane. | The structure of a [[GPCR|GPCR]] shows 7 transmembrane spans, with 3 exoloops and 4 cytoloops. The N-terminal is found on the outside of the membrane and the C-terminal found on the cytosolic side of the membrane. | ||
Revision as of 11:41, 13 November 2010
Guanine nucleotide binding protein that binds GTP when activated, which it hydrolyses to GDP. The active form of the protein can interact with a number of down stream effectors such as adenylyl cyclase (producing cAMP from ATP), and phospholipase C (PLC).
The G-proteins can be divided in to two families - the heterotrimeric G-proteins and the small or mono-meric G-proteins.
G-protein coupled receptors (GPCR) upon binding of stimulus activates G-protein.
The structure of a GPCR shows 7 transmembrane spans, with 3 exoloops and 4 cytoloops. The N-terminal is found on the outside of the membrane and the C-terminal found on the cytosolic side of the membrane.