Monomeric G-protein: Difference between revisions
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| A monomeric G-protein ( also known as small G protein or small GTPases, is the umbrella term for a family of signal transducing proteins. These comprise of: Rab, Arf, Ras, Ran and Rho, which are also vital in the growth of cells, as well as cell transport, motility, cytokinesis and cell differentiation.<ref>Berg et al., (2006) Biochemistry, 6th edition, New York. Pages 432</ref> Monomeric G proteins comprise of two forms, 1.) an 'inactive' form in which the monomeric G-protein is bound to GDP ( guanosine diphosphate), and 2.) the 'active' form in which the Monomeric G-protein is bound to GTP ( guanosine triphosphate). Notably, Monomeric G-proteins are small,( ranging around 20-25 Kd,) compared with larger types of G protein like Heterotrimeric proteins ( which are typically 30-35 Kd). <br> <br> <br> <br> References: | ||
A monomeric G-protein ( also known as small G protein or small GTPases, is the umbrella term for a family of signal transducing proteins. These comprise of: Rab, Arf, Ras, Ran and Rho, which are also vital in the growth of cells, as well as cell transport, motility, cytokinesis and cell differentiation. Monomeric G proteins comprise of two forms, 1.) an 'inactive' form in which the monomeric G-protein is bound to GDP ( guanosine diphosphate), and 2.) the 'active' form in which the Monomeric G-protein is bound to GTP ( guanosine triphosphate). Notably, Monomeric G-proteins are small,( ranging around 20-25 Kd,) compared with larger types of G protein like Heterotrimeric proteins ( which are typically 30-35 Kd). | |||
References: | |||
Revision as of 19:36, 13 November 2012
A monomeric G-protein ( also known as small G protein or small GTPases, is the umbrella term for a family of signal transducing proteins. These comprise of: Rab, Arf, Ras, Ran and Rho, which are also vital in the growth of cells, as well as cell transport, motility, cytokinesis and cell differentiation.[1] Monomeric G proteins comprise of two forms, 1.) an 'inactive' form in which the monomeric G-protein is bound to GDP ( guanosine diphosphate), and 2.) the 'active' form in which the Monomeric G-protein is bound to GTP ( guanosine triphosphate). Notably, Monomeric G-proteins are small,( ranging around 20-25 Kd,) compared with larger types of G protein like Heterotrimeric proteins ( which are typically 30-35 Kd).
References:
- ↑ Berg et al., (2006) Biochemistry, 6th edition, New York. Pages 432