MAP Kinase Kinase Kinase: Difference between revisions
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MAP (Mitogen-activating protein) Kinase Kinase Kinase ( also called MAP3K or MEKK, not MEK) is a type of protein kinase that [[Phosphorylation|phosphorylates]] other proteins, which include protein kinases such as [[MAP kinase kinase|Map Kinase Kinase ]](MEK). There is a family consisting of different types of MAP3Ks and they all react and respond to signals differently. It aids in intracellular control and helps determine the cells responses ; cell proliferation, cell death, hormonal responses and [[Differentiation|cell differentiation]]. It acts as a messenger in the transduction pathway in order to deliver a message to the cell therefore, this particular protein kinase can generate many different responses in the cell. <br> | MAP (Mitogen-activating protein) Kinase Kinase Kinase ( also called MAP3K or MEKK, not MEK) is a type of protein kinase that [[Phosphorylation|phosphorylates]] other proteins, which include protein kinases such as [[MAP kinase kinase|Map Kinase Kinase ]](MEK). There is a family consisting of different types of MAP3Ks and they all react and respond to signals differently. It aids in intracellular control and helps determine the cells responses ; cell proliferation, cell death, hormonal responses and [[Differentiation|cell differentiation]]. It acts as a messenger in the transduction pathway in order to deliver a message to the cell therefore, this particular protein kinase can generate many different responses in the cell. <ref>American chemical society (2001) MAP Kinases report. Available at: http://www.audreyli.com/panli/chemistry/reference/review/cr000241p.pdf (last accessed 23.11.2012)</ref><br> | ||
The function of MAP3K is that it phosphorylates the Serine or the Threonine residues of MEK. This can be shown through the [[RAS|RAS]] signalling pathway. RAS is a G -Protein that can be is associated with SOS ( Son of sevenless) and is activated by [[Enzyme-coupled Receptor|enzyme-coupled receptors in]] the plasma membrane ([[Monomeric G-protein|monomeric G proteins]]). RAS binds to MAP3K in order to activate it and as a result, it is able to phosphorylate MEK, which is the next transducing protein kinase in the signalling pathway. In this signalling process, the MAP3K is called RAF and without it, the cascade of protein kinase would not occur and target DNA is not expressed. | The function of MAP3K is that it phosphorylates the Serine or the Threonine residues of MEK. This can be shown through the [[RAS|RAS]] signalling pathway. RAS is a G -Protein that can be is associated with SOS ( Son of sevenless) and is activated by [[Enzyme-coupled Receptor|enzyme-coupled receptors in]] the plasma membrane ([[Monomeric G-protein|monomeric G proteins]]).<ref>The company of Biologists (2005) Journal of cell science 118. Available at: http://jcs.biologists.org/content/118/16/3569.full.pdf (last accessed 23.11.2012)</ref> RAS binds to MAP3K in order to activate it and as a result, it is able to phosphorylate MEK, which is the next transducing protein kinase in the signalling pathway. In this signalling process, the MAP3K is called RAF and without it, the cascade of protein kinase would not occur and target DNA is not expressed. <br> | ||
The MAP3Ks are activated by external signals such as growth factors ( EGF) and radiation<br> | The MAP3Ks are activated by external signals such as growth factors ( EGF) and radiation<br> | ||
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Revision as of 00:28, 23 November 2012
MAP (Mitogen-activating protein) Kinase Kinase Kinase ( also called MAP3K or MEKK, not MEK) is a type of protein kinase that phosphorylates other proteins, which include protein kinases such as Map Kinase Kinase (MEK). There is a family consisting of different types of MAP3Ks and they all react and respond to signals differently. It aids in intracellular control and helps determine the cells responses ; cell proliferation, cell death, hormonal responses and cell differentiation. It acts as a messenger in the transduction pathway in order to deliver a message to the cell therefore, this particular protein kinase can generate many different responses in the cell. [1]
The function of MAP3K is that it phosphorylates the Serine or the Threonine residues of MEK. This can be shown through the RAS signalling pathway. RAS is a G -Protein that can be is associated with SOS ( Son of sevenless) and is activated by enzyme-coupled receptors in the plasma membrane (monomeric G proteins).[2] RAS binds to MAP3K in order to activate it and as a result, it is able to phosphorylate MEK, which is the next transducing protein kinase in the signalling pathway. In this signalling process, the MAP3K is called RAF and without it, the cascade of protein kinase would not occur and target DNA is not expressed.
The MAP3Ks are activated by external signals such as growth factors ( EGF) and radiation
- ↑ American chemical society (2001) MAP Kinases report. Available at: http://www.audreyli.com/panli/chemistry/reference/review/cr000241p.pdf (last accessed 23.11.2012)
- ↑ The company of Biologists (2005) Journal of cell science 118. Available at: http://jcs.biologists.org/content/118/16/3569.full.pdf (last accessed 23.11.2012)