Calmodulin: Difference between revisions
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Created page with 'Calcium binding protein involved in intracellular calcium signalling. <ref>Alberts et al. Molecular Biology of the Cell (5th Ed)</ref> <u>'''…' |
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[[Calcium|Calcium binding]] protein involved in [[Calcium signalling|intracellular calcium signalling.]] <ref>Alberts et al. Molecular Biology of the Cell (5th Ed)</ref> | [[Calcium|Calcium binding]] protein involved in [[Calcium signalling|intracellular calcium signalling.]] <ref>Alberts et al. Molecular Biology of the Cell (5th Ed)</ref> | ||
=== Structure === | |||
Highly conserved sequence of 152 [[Amino acids|amino acids]] <ref>http://www.ncbi.nlm.nih.gov/protein/CAA36839.1</ref> | Highly conserved sequence of 152 [[Amino acids|amino acids]] <ref>http://www.ncbi.nlm.nih.gov/protein/CAA36839.1</ref> | ||
There are four [[EFh domains|EFh domains]] which are responsible for | There are four [[EFh domains|EFh domains]] which are responsible for Ca<sup>2+</sup> binding <ref>http://smart.embl-heidelberg.de/smart/job_status.pl?jobid=939661123169621289746763YwAuDuwGQT</ref><br> | ||
< | === <u</u>Function<u</u> === | ||
<u> | |||
Calmodulin binds Ca<sup>2+</sup> to maintain low cytosolic Ca<sup>2+</sup> concentration | Calmodulin binds Ca<sup>2+</sup> to maintain low cytosolic Ca<sup>2+</sup> concentration | ||
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Two or more Ca<sup>2+</sup> ions bind to induce a [[Conformational change|conformational change]] and activate calmodulin <ref>Alberts et al. Molecular Biology of the Cell (5th Ed)</ref> | Two or more Ca<sup>2+</sup> ions bind to induce a [[Conformational change|conformational change]] and activate calmodulin <ref>Alberts et al. Molecular Biology of the Cell (5th Ed)</ref> | ||
=== References === | |||
<references /> | <references /> | ||
Revision as of 15:47, 14 November 2010
Calcium binding protein involved in intracellular calcium signalling. [1]
Structure
Highly conserved sequence of 152 amino acids [2]
There are four EFh domains which are responsible for Ca2+ binding [3]
<uFunction<u
Calmodulin binds Ca2+ to maintain low cytosolic Ca2+ concentration
Two or more Ca2+ ions bind to induce a conformational change and activate calmodulin [4]
References
- ↑ Alberts et al. Molecular Biology of the Cell (5th Ed)
- ↑ http://www.ncbi.nlm.nih.gov/protein/CAA36839.1
- ↑ http://smart.embl-heidelberg.de/smart/job_status.pl?jobid=939661123169621289746763YwAuDuwGQT
- ↑ Alberts et al. Molecular Biology of the Cell (5th Ed)