Multi-drug resistance (MDR): Difference between revisions
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Multi-drug resistance is a condition where [[Cancer|cancer]] cells are resistant to chemotherapy drugs due to the presence on a drug eflux pump called the [[P-glycoprotein|p-glycoprotein]] that actively pumps out drugs from the cell. P-glycoprotein in normal gut [[Epithelial cells|epithelial cells]] help to expell toxic substances in the food we eat, but this is up-regulated in [[Cancer|cancer]] cells. The p-[[Glycoprotein|glycoprotein]] is part of the [[ABC transporter superfamily|ABC transporter superfamily]]. | Multi-drug resistance is a condition where [[Cancer|cancer]] cells are resistant to [[Chemotherapy|chemotherapy]] drugs due to the presence on a drug eflux pump called the [[P-glycoprotein|p-glycoprotein]] that actively pumps out drugs from the cell. [[P-glycoprotein|P-glycoprotein]] in normal gut [[Epithelial cells|epithelial cells]] help to expell toxic substances in the food we eat, but this is up-regulated in [[Cancer|cancer]] cells. The p-[[Glycoprotein|glycoprotein]] is part of the [[ABC transporter superfamily|ABC transporter superfamily]]. | ||
Revision as of 14:31, 14 October 2013
Multi-drug resistance is a condition where cancer cells are resistant to chemotherapy drugs due to the presence on a drug eflux pump called the p-glycoprotein that actively pumps out drugs from the cell. P-glycoprotein in normal gut epithelial cells help to expell toxic substances in the food we eat, but this is up-regulated in cancer cells. The p-glycoprotein is part of the ABC transporter superfamily.