Parkinson's Disease: Difference between revisions
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Parkinson’s disease is an [[idiopathic|idiopathic]] and has no known cause. It is normally due to the degeneration of [[dopaminergic neurone|dopaminergic neurones]] of the nigrostriatal tract and loss of DA neurotransmission in the striatum. The symptoms of this disease are a resting tremor, muscle rigidity and suppression of voluntary movements (hypokinesis). | |||
The main 4 dopaminergic pathways are:- | |||
< | #<span style="line-height: 1.5em;">Nigrostriatal - </span>Substantia nigra to [[Striatum|striatum]] | ||
#[[Striatum|Striatum]]<span style="line-height: 1.5em;">Mesolimbic - </span>Ventral tegmental area to nucleus accumbens | |||
#<span style="line-height: 1.5em;">Mesocortical - </span>Ventral tegmental area to [[Frontal cortex|frontal cortex]] | |||
#[[Frontal cortex|Frontal cortex]]<span style="line-height: 1.5em;">Tuberoinfundibular - </span>Arcuate nucleus to [[Pituitary gland|pituitary gland]] | |||
< | <span style="line-height: 1.5em;">The decarboxylase inhibitor – carbidopa, the </span>[[MAO|MAO inhibitor]]<span style="line-height: 1.5em;">: Selegiline and </span>[[D2 receptor|D2 receptor agonists]]<span style="line-height: 1.5em;"> like [[Bromocriptine|Bromocriptine]] can be used to treat Parkinson’s disease.</span> | ||
Revision as of 01:03, 20 October 2013
Parkinson’s disease is an idiopathic and has no known cause. It is normally due to the degeneration of dopaminergic neurones of the nigrostriatal tract and loss of DA neurotransmission in the striatum. The symptoms of this disease are a resting tremor, muscle rigidity and suppression of voluntary movements (hypokinesis).
The main 4 dopaminergic pathways are:-
- Nigrostriatal - Substantia nigra to striatum
- StriatumMesolimbic - Ventral tegmental area to nucleus accumbens
- Mesocortical - Ventral tegmental area to frontal cortex
- Frontal cortexTuberoinfundibular - Arcuate nucleus to pituitary gland
The decarboxylase inhibitor – carbidopa, the MAO inhibitor: Selegiline and D2 receptor agonists like Bromocriptine can be used to treat Parkinson’s disease.