Proteasome: Difference between revisions
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As stated in the paper of Peters, ''et al.'', 1994: "Proteasomes are very large [[Protein|protein]] complexes found in some of the living [[Organism|organisms]]" <ref>Peters, Jan-Michael; Franke, Werner W.; Kleinschmidt, Jiirgen A. (March 1994). "Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm". The Journal of Biological Chemistry 269 (10): 7709–18. PMID 8125997</ref>. | As stated in the paper of Peters, ''et al.'', 1994: "Proteasomes are very large [[Protein|protein]] complexes found in some of the living [[Organism|organisms]]" <ref>Peters, Jan-Michael; Franke, Werner W.; Kleinschmidt, Jiirgen A. (March 1994). "Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm". The Journal of Biological Chemistry 269 (10): 7709–18. PMID 8125997</ref>. | ||
Proteasomes have a key essential role in the [[Cell|cell]] by controling the [[Protein|protein]] and degrading the [[Amino acids|amino acids]] creating new [[Proteins|proteins]] <ref>Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipursky SL, Darnell J (2004). "3". Molecular cell biology (5th ed.). New York: W.H. Freeman and CO. pp. 66–72. ISBN 0-7167-4366-3.</ref>.<br> | Proteasomes have a key essential role in the [[Cell|cell]] by controling the [[Protein|protein]] and degrading the [[Amino acids|amino acids]] creating new [[Proteins|proteins]] <ref>Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipursky SL, Darnell J (2004). "3". Molecular cell biology (5th ed.). New York: W.H. Freeman and CO. pp. 66–72. ISBN 0-7167-4366-3.</ref>.<br> | ||
In addition, proteasome controls cell-cycle progression and | In addition, proteasome controls cell-cycle progression and [[Apoptosis|apoptosis]] which act as crutial target in anti-cancer therapy<ref>The proteasome: structure, function, and role in the cell. http://www.ncbi.nlm.nih.gov/pubmed/12738238. 2003 May;29 Suppl 1:3-9</ref>. | ||
=== References:<br> | === References:<br> === | ||
<references /><br> | <references /><br> | ||
Revision as of 13:40, 24 October 2017
As stated in the paper of Peters, et al., 1994: "Proteasomes are very large protein complexes found in some of the living organisms" [1].
Proteasomes have a key essential role in the cell by controling the protein and degrading the amino acids creating new proteins [2].
In addition, proteasome controls cell-cycle progression and apoptosis which act as crutial target in anti-cancer therapy[3].
References:
- ↑ Peters, Jan-Michael; Franke, Werner W.; Kleinschmidt, Jiirgen A. (March 1994). "Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm". The Journal of Biological Chemistry 269 (10): 7709–18. PMID 8125997
- ↑ Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipursky SL, Darnell J (2004). "3". Molecular cell biology (5th ed.). New York: W.H. Freeman and CO. pp. 66–72. ISBN 0-7167-4366-3.
- ↑ The proteasome: structure, function, and role in the cell. http://www.ncbi.nlm.nih.gov/pubmed/12738238. 2003 May;29 Suppl 1:3-9