Clathrin: Difference between revisions
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Clathrin is a [[Protein|protein]] heavily involved in the creation of [[ | Clathrin is a [[Protein|protein]] heavily involved in the creation of [[Coated vesicles|coated vesicles]], it also allows for the trafficking inside cell pathways, mechanisms and regulation. It forms a polyhedral (soccer-ball-shaped) lattice made up of many clathrin molecules that coats a new vesicle as it forms and also helps in protein sorting<ref>J.A. Ybe et al., Nature 399 (1999), 371-375.</ref>.<br>Vesicles do not form spontaneously, but rather, are facilitated by coat-proteins like clathrin. Clathrin doesn't bind directly to a membrane to form vesicles; instead, it binds to adaptor proteins that recognize molecules on a membrane surface. At least 20 different clathrin adaptors have been identified, each recognizing and binding to membrane proteins and phospholipids that are unique to a particular organelle<ref>RCSB Molecule of the Month by Graham T. Johnson and David Goodsell (April 2007)</ref>. <br>During vesicle transport, cargo-loaded vesicles form at a donor compartment, with the help of the specialised clathrin coat. It is one of three types of coating. <br>Clathrin-dependent endocytosis is the process by which cells undergo endocytosis by the inward budding of plasma membrane<ref>Trafficking inside cells, pathways, mechanisms and regulation – Nava Segar Springer Lin (c2009) pages 7-9</ref>. <br> | ||
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Revision as of 15:47, 29 November 2013
Clathrin is a protein heavily involved in the creation of coated vesicles, it also allows for the trafficking inside cell pathways, mechanisms and regulation. It forms a polyhedral (soccer-ball-shaped) lattice made up of many clathrin molecules that coats a new vesicle as it forms and also helps in protein sorting[1].
Vesicles do not form spontaneously, but rather, are facilitated by coat-proteins like clathrin. Clathrin doesn't bind directly to a membrane to form vesicles; instead, it binds to adaptor proteins that recognize molecules on a membrane surface. At least 20 different clathrin adaptors have been identified, each recognizing and binding to membrane proteins and phospholipids that are unique to a particular organelle[2].
During vesicle transport, cargo-loaded vesicles form at a donor compartment, with the help of the specialised clathrin coat. It is one of three types of coating.
Clathrin-dependent endocytosis is the process by which cells undergo endocytosis by the inward budding of plasma membrane[3].
References