Microvilli: Difference between revisions
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Microvilli are thin, finger-like projections on the surface of cells and are particularly abundant in [[Epithelial cells|epithelia]], where a large surface area is required for effiecient function. | Microvilli are thin, finger-like projections on the surface of cells and are particularly abundant in [[Epithelial cells|epithelia]], where a large surface area is required for effiecient function. | ||
Each microvilli has about 20-30 parrellel [[Actin filaments|actin filaments]] that extend from the tip into the cell cortex. In all the actin filaments the plus ends point away from the cell body and are held together by actin-bundling proteins- the most important of which is villin, a protein that is specific to microvilli and cross-links actin filaments into tight bundles. | Each microvilli has about 20-30 parrellel [[Actin filaments|actin filaments]] that extend from the tip into the cell cortex. In all the actin filaments the plus ends point away from the cell body and are held together by actin-bundling proteins- the most important of which is villin, a [[protein|protein]] that is specific to microvilli and cross-links actin filaments into tight bundles. | ||
At the base of each microvillus, the actin filaments are anchored into a specialized region known as the terminal web, which contains and concentrated net-work of spectrin molecules and a layter of intermediate filaments. It is | At the base of each microvillus, the actin filaments are anchored into a specialized region known as the terminal web, which contains and concentrated net-work of spectrin molecules and a layter of [[intermediate filaments|intermediate filaments]]. It is thought that spectrin imparts rigidity to the cell cortex; because the actin filaments are anchored to the terminal web, this keeps the microvilli orientated perpendicularly to the apical surface of the cell. The [[actin|actin]] filaments are attacted to the [[plasma membrane|plasma membrane]] by lateral bridges composed of [[myosin-I|myosin-I]] and serveral other [[molecules|molecules]] including the Ca<sup>2+</sup>. <ref>G M. Fuller and D, Shiels. Molecular Basis of Medical Cell Biology (1998) 1st edition. Chapter 7 PP.140-141</ref><br> | ||
=== Reference === | === Reference === | ||
<references /> | <references /> | ||
Revision as of 02:32, 30 November 2013
Microvilli are thin, finger-like projections on the surface of cells and are particularly abundant in epithelia, where a large surface area is required for effiecient function.
Each microvilli has about 20-30 parrellel actin filaments that extend from the tip into the cell cortex. In all the actin filaments the plus ends point away from the cell body and are held together by actin-bundling proteins- the most important of which is villin, a protein that is specific to microvilli and cross-links actin filaments into tight bundles.
At the base of each microvillus, the actin filaments are anchored into a specialized region known as the terminal web, which contains and concentrated net-work of spectrin molecules and a layter of intermediate filaments. It is thought that spectrin imparts rigidity to the cell cortex; because the actin filaments are anchored to the terminal web, this keeps the microvilli orientated perpendicularly to the apical surface of the cell. The actin filaments are attacted to the plasma membrane by lateral bridges composed of myosin-I and serveral other molecules including the Ca2+. [1]
Reference
- ↑ G M. Fuller and D, Shiels. Molecular Basis of Medical Cell Biology (1998) 1st edition. Chapter 7 PP.140-141