DNA topoisimerase: Difference between revisions
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1. Alberts, BA, 2008. Molecular Biology of The Cell. 5th ed. New York: Garland Science. | 1. Alberts, BA, 2008. Molecular Biology of The Cell. 5th ed. New York: Garland Science. | ||
Revision as of 05:09, 12 October 2014
DNA topoisomerase plays an impotant role in breaking the phosophodiester bond by binding covalently onto the DNA backbone phosphate. It acst as a reversible nuclease. This whole process is a reversible one, whereby before the protein leaves, the phosophodiester bonds are re-made. There are two types of DNA topoisomerase, topoisomerase I and topoismerase II.
Reference:
1. Alberts, BA, 2008. Molecular Biology of The Cell. 5th ed. New York: Garland Science.