Cyclic AMP: Difference between revisions
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Cyclic AMP (cAMP) is a [[Second messengers|secondary messenger]] used in cell signalling. It is synthesised from [[ATP|ATP]] by the [[Enzyme|enzyme]] [[Adenylyl cyclase|adenylyl cyclase]]. It is continuously destroyed by cylcic AMP phosphodiesterases that will hydrolyze cyclic AMP to adenosine 5'monophosphate (5'-AMP).<ref>Alberts et al. (2008). "Molecular Biology of the Cell" ( | Cyclic AMP (cAMP) is a [[Second messengers|secondary messenger]] used in cell signalling. It is synthesised from [[ATP|ATP]] by the [[Enzyme|enzyme]] [[Adenylyl cyclase|adenylyl cyclase]]. It is continuously destroyed by cylcic AMP phosphodiesterases that will hydrolyze cyclic AMP to adenosine 5'monophosphate (5'-AMP).<ref>Alberts et al. (2008). "Molecular Biology of the Cell" (4th edition); page 855</ref> | ||
The concentration within a cell of cyclic AMP is normally around 10<sup>-7 </sup>however an extracellular signal can raise those levels within the cell by a factor of 20 within seconds.<ref>Alberts et al. (2008). "Molecular Biology of the Cell" ( | The concentration within a cell of cyclic AMP is normally around 10<sup>-7 </sup>however an extracellular signal can raise those levels within the cell by a factor of 20 within seconds.<ref>Alberts et al. (2008). "Molecular Biology of the Cell" (4th edition); page 854</ref> <sup></sup>Production of cyclic AMP results in the activation of [[Protein kinase A|Protein kinase A]], which triggers cellular responses by activating [[Enzymes|enzymes]], stimulating cellular secretion or opening ion channels<ref>Alberts et al. (2008). "Molecular Biology of the Cell" (5th edition); page 906</ref>. | ||
=== References === | === References === | ||
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Revision as of 12:19, 20 October 2014
Cyclic AMP (cAMP) is a secondary messenger used in cell signalling. It is synthesised from ATP by the enzyme adenylyl cyclase. It is continuously destroyed by cylcic AMP phosphodiesterases that will hydrolyze cyclic AMP to adenosine 5'monophosphate (5'-AMP).[1]
The concentration within a cell of cyclic AMP is normally around 10-7 however an extracellular signal can raise those levels within the cell by a factor of 20 within seconds.[2] Production of cyclic AMP results in the activation of Protein kinase A, which triggers cellular responses by activating enzymes, stimulating cellular secretion or opening ion channels[3].