Penetrance: Difference between revisions
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Penetrance is the percentage of the expression of the [[Phenotype|phenotype]] in an [[Organism|organism]] from its adjacent [[Genotype|genotype]] <ref>Hartl, D.L., Ruvolo, M. (2012) Genetics:Analysis Of Genes And Genomes, United States of America: Jones and Bartlett</ref>. | Penetrance is the percentage of the expression of the [[Phenotype|phenotype]] in an [[Organism|organism]] from its adjacent [[Genotype|genotype]] <ref>Hartl, D.L., Ruvolo, M. (2012) Genetics:Analysis Of Genes And Genomes, United States of America: Jones and Bartlett</ref>, ie. how many members of a population with a specific genotype that show the expected phenotype. | ||
An example of complete pentrance is neurofibromatosis type 1. The symptoms of this mutation will be shown in all of the mutants - 100% penetrance. <ref>NHS. (ND). Penetrance. Available at: http://www.geneticseducation.nhs.uk/genetic-glossary/221-penetrance (Accessed at: 26/11/14)</ref> | |||
Incomplete penetrance is when some individuals with a particular (dominant) mutation express a wild type phenotype.An example is polydactyly. | |||
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Revision as of 16:48, 26 November 2014
Penetrance is the percentage of the expression of the phenotype in an organism from its adjacent genotype [1], ie. how many members of a population with a specific genotype that show the expected phenotype.
An example of complete pentrance is neurofibromatosis type 1. The symptoms of this mutation will be shown in all of the mutants - 100% penetrance. [2]
Incomplete penetrance is when some individuals with a particular (dominant) mutation express a wild type phenotype.An example is polydactyly.
Reference
- ↑ Hartl, D.L., Ruvolo, M. (2012) Genetics:Analysis Of Genes And Genomes, United States of America: Jones and Bartlett
- ↑ NHS. (ND). Penetrance. Available at: http://www.geneticseducation.nhs.uk/genetic-glossary/221-penetrance (Accessed at: 26/11/14)