Desmosomes: Difference between revisions
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In desomsome junctions a bundle of intermediate filaments is attached to a plaque of anchor proteins. Also attached to the plaque are transmembrane adhesion proteins of the cadherin family which hold the adjacent membranes together. These proteins are desmoglein and desmocolli <ref>Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P. (2007). Molecular Biology of the cell (Fifth ed.). Garland Science.</ref>.<br> | In desomsome junctions a bundle of intermediate filaments is attached to a plaque of anchor proteins. Also attached to the plaque are transmembrane adhesion proteins of the cadherin family which hold the adjacent membranes together. These proteins are desmoglein and desmocolli <ref>Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P. (2007). Molecular Biology of the cell (Fifth ed.). Garland Science.</ref>.<br> | ||
The main function of desmosome junctions is to provide mechanical strength to the cell. If the desmosome junction is disrupted, for example by [[Antibodies|antibodies]] which cause defective adhesion, severe blistering of the skin can occur<ref>Garrod, D., Chidgey , M. (2007). Desmosome structure, composition and function. Science Direct .</ref>. The plaque made up of anchor proteins, is linked to the intermediate filaments (usually comprised of alpha keratin) between cells, creating a network throughout the tissue. The network is maintained by desmosome junctions clustering together, to form adhesion belts<ref>Bruce Alberts Alexander Johnson Julian Lewis Martin Raff Keith Roberts Peter Walter in Molecular Biology of the Cell fifth editiom</ref> which further increase their ability to provide mechanical strength <ref>Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P. (2007). Molecular Biology of the cell (Fifth ed.). Garland Science.</ref>. | The main function of desmosome junctions is to provide mechanical strength to the cell. If the desmosome junction is disrupted, for example by [[Antibodies|antibodies]] which cause defective adhesion, severe blistering of the skin can occur<ref>Garrod, D., Chidgey , M. (2007). Desmosome structure, composition and function. Science Direct .</ref>. The plaque made up of anchor proteins, is linked to the intermediate filaments (usually comprised of alpha keratin) between cells, creating a network throughout the tissue. The network is maintained by desmosome junctions clustering together, to form adhesion belts<ref name="null">Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts and Peter Walter in Molecular Biology of the Cell fifth editiom</ref> which further increase their ability to provide mechanical strength <ref>Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P. (2007). Molecular Biology of the cell (Fifth ed.). Garland Science.</ref>. | ||
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Revision as of 12:44, 28 November 2014
Desmosome junctions are a type of anchoring junction. Anchoring junctions are cell-cell junctions where there is a central role played by transmembrane adhesion proteins that span the membrane. One end of the protein links to the cytoskeleton inside the cell whereas the other end links to other structures outside the cell. There are two types of anchoring junctions: adherens junction and desmosome junctions [1].
In desomsome junctions a bundle of intermediate filaments is attached to a plaque of anchor proteins. Also attached to the plaque are transmembrane adhesion proteins of the cadherin family which hold the adjacent membranes together. These proteins are desmoglein and desmocolli [2].
The main function of desmosome junctions is to provide mechanical strength to the cell. If the desmosome junction is disrupted, for example by antibodies which cause defective adhesion, severe blistering of the skin can occur[3]. The plaque made up of anchor proteins, is linked to the intermediate filaments (usually comprised of alpha keratin) between cells, creating a network throughout the tissue. The network is maintained by desmosome junctions clustering together, to form adhesion belts[4] which further increase their ability to provide mechanical strength [5].
References
- ↑ Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P. (2007). Molecular Biology of the cell (Fifth ed.). Garland Science.
- ↑ Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P. (2007). Molecular Biology of the cell (Fifth ed.). Garland Science.
- ↑ Garrod, D., Chidgey , M. (2007). Desmosome structure, composition and function. Science Direct .
- ↑ Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts and Peter Walter in Molecular Biology of the Cell fifth editiom
- ↑ Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P. (2007). Molecular Biology of the cell (Fifth ed.). Garland Science.
- ↑ Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P. (2007). Molecular Biology of the cell (Fifth ed.). Garland Science.
- ↑ Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P. (2007). Molecular Biology of the cell (Fifth ed.). Garland Science.
- ↑ Garrod, D., Chidgey , M. (2007). Desmosome structure, composition and function. Science Direct .
- ↑ Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts and Peter Walter in Molecular Biology of the Cell fifth editiom
- ↑ Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P. (2007). Molecular Biology of the cell (Fifth ed.). Garland Science.