Sickle Cell: Difference between revisions
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Sickle cells<ref>Sickle cells http://www.nhs.uk/Conditions/Sickle-cell-anaemia/Pages/Introduction.aspx May 21, 2014.</ref> are rigid and shaped like a crescent unlike normal [[ | Sickle cells<ref>Sickle cells http://www.nhs.uk/Conditions/Sickle-cell-anaemia/Pages/Introduction.aspx May 21, 2014.</ref> are rigid and shaped like a crescent unlike normal [[Red blood cells|red blood cells which]] are more flexible and disc-shaped. This abnormal shape makes it harder for the cells to move around and can lead to blockage in [[Blood vessels|blood vessels resulting]] in [[Tissue|tissue]] and [[Organ|organ]] damage. | ||
These sickle cells have shorter life span compared to normal blood cells. Individuals with sickle cell would eventually suffer from [[Anaemia|anaemia]], which is a shortage of [[ | These sickle cells have shorter life span compared to normal blood cells. Individuals with sickle cell would eventually suffer from [[Anaemia|anaemia]], which is a shortage of [[Red blood cells|red blood cells]]. | ||
The cause of this discernible shape is due to a change in structure of [[Haemoglobin|haemoglobin]] molecules. [[Haemoglobin|Haemoglobin]] molecules contain alpha and beta units. In sickle cell anaemia, there is a [[Gene|gene]] [[Mutation|mutation]] on [[Chromosome|chromosome]] 11 of the beta subunit. This [[Mutation|mutation]] causes the [[Haemoglobin|haemoglobin]] molecules to join into long, inflexible chains, causing the sickle-cell shape. | The cause of this discernible shape is due to a change in structure of [[Haemoglobin|haemoglobin]] molecules. [[Haemoglobin|Haemoglobin]] molecules contain alpha and beta units. In sickle cell anaemia, there is a [[Gene|gene]] [[Mutation|mutation]] on [[Chromosome|chromosome]] 11 of the beta subunit. This [[Mutation|mutation]] causes the [[Haemoglobin|haemoglobin]] molecules to join into long, inflexible chains, causing the sickle-cell shape.<ref>(2015) Sickle Cell Disease. [online]. University of Utah. Available at: http://learn.genetics.utah.edu/content/disorders/singlegene/sicklecell/ [Accessed: 19/10/2015]</ref> | ||
Refer to [[Sickle cell anaemia|Sickle Cell Anaemia]] for more information. | Refer to [[Sickle cell anaemia|Sickle Cell Anaemia]] for more information. | ||
Latest revision as of 14:38, 19 October 2015
Sickle cells[1] are rigid and shaped like a crescent unlike normal red blood cells which are more flexible and disc-shaped. This abnormal shape makes it harder for the cells to move around and can lead to blockage in blood vessels resulting in tissue and organ damage.
These sickle cells have shorter life span compared to normal blood cells. Individuals with sickle cell would eventually suffer from anaemia, which is a shortage of red blood cells.
The cause of this discernible shape is due to a change in structure of haemoglobin molecules. Haemoglobin molecules contain alpha and beta units. In sickle cell anaemia, there is a gene mutation on chromosome 11 of the beta subunit. This mutation causes the haemoglobin molecules to join into long, inflexible chains, causing the sickle-cell shape.[2]
Refer to Sickle Cell Anaemia for more information.
Reference
- ↑ Sickle cells http://www.nhs.uk/Conditions/Sickle-cell-anaemia/Pages/Introduction.aspx May 21, 2014.
- ↑ (2015) Sickle Cell Disease. [online]. University of Utah. Available at: http://learn.genetics.utah.edu/content/disorders/singlegene/sicklecell/ [Accessed: 19/10/2015]