Activator: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
Activator domains are modular proteins that stimulate [[Transcription|transcription]] via communicating with the transcription machinery "[[Pre-initation complex|pre-initation complex]]" (PIC).<ref>Lodish, H. et al.,2007.Molecular Cell Biology.Sixth Edition.New york:W.H.Freeman &amp;amp;amp; Co Ltd.</ref><br> | Activator domains are modular proteins that stimulate [[Transcription|transcription]] via communicating with the transcription machinery "[[Pre-initation complex|pre-initation complex]]" (PIC).<ref>Lodish, H. et al.,2007.Molecular Cell Biology.Sixth Edition.New york:W.H.Freeman &amp;amp;amp;amp; Co Ltd.</ref><br> | ||
== Activators mechanisms == | == Activators mechanisms == | ||
They work synergistically as it promotes binding of an additional activator. The binding of one activator on a UAS induces a binding of another. Together these two have a greater effect on enhancing transcription than just the total of both acting independently. They bind to an enhancer to facilitate either the recruitment of RNA polymerase II to the promoter region or its elongation .<ref name="null">http://www.ncbi.nlm.nih.gov/pubmed/22180087</ref> | They work synergistically as it promotes binding of an additional activator. The binding of one activator on a UAS induces a binding of another. Together these two have a greater effect on enhancing transcription than just the total of both acting independently. They bind to an enhancer to facilitate either the recruitment of RNA polymerase II to the promoter region or its elongation .<ref name="null">http://www.ncbi.nlm.nih.gov/pubmed/22180087</ref> <ref>transcriptional activators and mechanisms (http://www.ncbi.nlm.nih.gov/pubmed/22180087)</ref> | ||
=== References === | === References === | ||
<references /> | <references /> | ||
Revision as of 12:59, 27 October 2015
Activator domains are modular proteins that stimulate transcription via communicating with the transcription machinery "pre-initation complex" (PIC).[1]
Activators mechanisms
They work synergistically as it promotes binding of an additional activator. The binding of one activator on a UAS induces a binding of another. Together these two have a greater effect on enhancing transcription than just the total of both acting independently. They bind to an enhancer to facilitate either the recruitment of RNA polymerase II to the promoter region or its elongation .[2] [3]
References
- ↑ Lodish, H. et al.,2007.Molecular Cell Biology.Sixth Edition.New york:W.H.Freeman &amp;amp;amp; Co Ltd.
- ↑ http://www.ncbi.nlm.nih.gov/pubmed/22180087
- ↑ transcriptional activators and mechanisms (http://www.ncbi.nlm.nih.gov/pubmed/22180087)