G-protein linked receptor: Difference between revisions
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G-protein linked receptors, also known as [[G-protein Coupled Receptor|G-protein Coupled receptors]] (GPCR), are a family of receptor signal transducers which are involved in signalling pathways within cells <ref>Cascieri.Fong.Graziano.Tota.Candelore.Strader. (1996) ‘Signaling through G-Protein-coupled Receptors’, pg93, in Heldin,C. Purton,M and International Union of Biochemistry and Molecular Biology. (ed) Signal Transduction, London: Chapman &amp;amp;amp; Hall in association with the IUBMB</ref>. Subtypes, each with an endogenous [[Agonist|agonist]], are involved in maintaining physiological systems such as [[Rhodopsin|rhodopsin]] in [[Rod cells|rod cells]] required for vision <ref>Cascieri.Fong.Graziano.Tota.Candelore.Strader. (1996) ‘Signaling through G-Protein-coupled Receptors’, pg94, in Heldin,C. Purton,M and International Union of Biochemistry and Molecular Biology. (ed) Signal Transduction, London: Chapman &amp;amp;amp; Hall in association with the IUBMB</ref>.<br> | G-protein linked receptors, also known as [[G-protein Coupled Receptor|G-protein Coupled receptors]] (GPCR), are a family of receptor signal transducers which are involved in signalling pathways within cells <ref>Cascieri.Fong.Graziano.Tota.Candelore.Strader. (1996) ‘Signaling through G-Protein-coupled Receptors’, pg93, in Heldin,C. Purton,M and International Union of Biochemistry and Molecular Biology. (ed) Signal Transduction, London: Chapman &amp;amp;amp;amp; Hall in association with the IUBMB</ref>.They can be further divided into to monomeric and trimeric regarding how many components mak up the G-prootein in question. Subtypes, each with an endogenous [[Agonist|agonist]], are involved in maintaining physiological systems such as [[Rhodopsin|rhodopsin]] in [[Rod cells|rod cells]] required for vision <ref>Cascieri.Fong.Graziano.Tota.Candelore.Strader. (1996) ‘Signaling through G-Protein-coupled Receptors’, pg94, in Heldin,C. Purton,M and International Union of Biochemistry and Molecular Biology. (ed) Signal Transduction, London: Chapman &amp;amp;amp;amp; Hall in association with the IUBMB</ref>.<br> | ||
=== Structure === | === Structure === | ||
The structure of these proteins comprises of seven [[Transmembrane helices|transmembrane helices]] with an extracellular ligand binding domain and an intracellular G-protein binding domain <ref>Cascieri.Fong.Graziano.Tota.Candelore.Strader. (1996) ‘Signaling through G-Protein-coupled Receptors’, pg94, in Heldin,C. Purton,M and International Union of Biochemistry and Molecular Biology. (ed) Signal Transduction, London: Chapman &amp;amp;amp; Hall in association with the IUBMB</ref>.<br> | The structure of these proteins comprises of seven [[Transmembrane helices|transmembrane helices]] with an extracellular ligand binding domain and an intracellular G-protein binding domain <ref>Cascieri.Fong.Graziano.Tota.Candelore.Strader. (1996) ‘Signaling through G-Protein-coupled Receptors’, pg94, in Heldin,C. Purton,M and International Union of Biochemistry and Molecular Biology. (ed) Signal Transduction, London: Chapman &amp;amp;amp;amp; Hall in association with the IUBMB</ref>.<br> | ||
=== References === | === References === | ||
<references /> | <references /> | ||
Revision as of 21:14, 25 November 2015
G-protein linked receptors, also known as G-protein Coupled receptors (GPCR), are a family of receptor signal transducers which are involved in signalling pathways within cells [1].They can be further divided into to monomeric and trimeric regarding how many components mak up the G-prootein in question. Subtypes, each with an endogenous agonist, are involved in maintaining physiological systems such as rhodopsin in rod cells required for vision [2].
Structure
The structure of these proteins comprises of seven transmembrane helices with an extracellular ligand binding domain and an intracellular G-protein binding domain [3].
References
- ↑ Cascieri.Fong.Graziano.Tota.Candelore.Strader. (1996) ‘Signaling through G-Protein-coupled Receptors’, pg93, in Heldin,C. Purton,M and International Union of Biochemistry and Molecular Biology. (ed) Signal Transduction, London: Chapman &amp;amp;amp; Hall in association with the IUBMB
- ↑ Cascieri.Fong.Graziano.Tota.Candelore.Strader. (1996) ‘Signaling through G-Protein-coupled Receptors’, pg94, in Heldin,C. Purton,M and International Union of Biochemistry and Molecular Biology. (ed) Signal Transduction, London: Chapman &amp;amp;amp; Hall in association with the IUBMB
- ↑ Cascieri.Fong.Graziano.Tota.Candelore.Strader. (1996) ‘Signaling through G-Protein-coupled Receptors’, pg94, in Heldin,C. Purton,M and International Union of Biochemistry and Molecular Biology. (ed) Signal Transduction, London: Chapman &amp;amp;amp; Hall in association with the IUBMB